Researching asthma across the ages: Insights from the National Heart, Lung, and Blood Institute's Asthma Network

Michael D. Cabana, Susan J. Kunselman, Sharmilee M. Nyenhuis, Michael E. Wechsler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Clinical asthma studies across different age groups (ie, cross-age studies) can potentially offer insight into the similarities, differences, and relationships between childhood and adult asthma. The National Institutes of Health's Asthma Research Network (AsthmaNet) is unique and innovative in that it has merged pediatric and adult asthma research into a single clinical research network. This combination enhances scientific exchange between pediatric and adult asthma investigators and encourages the application of cross-age studies that involve participants from multiple age groups who are generally not studied together. The experience from AsthmaNet in the development of cross-age protocols highlights some of the issues in the evaluation of cross-age research in asthma. The aim of this review is to summarize these challenges, including the selection of parallel cross-age clinical interventions, identification of appropriate controls, measurement of meaningful clinical outcomes, and various ethical and logistic issues.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Asthma
  • clinical trials
  • outcome measures
  • participant recruitment
  • pediatric assent
  • pediatric consent
  • study design

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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