Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats

Kristi L. Helke, David K. Meyerholz, Amanda P. Beck, Eric R. Burrough, Rachel J. Derscheid, Christiane Lohr, Elizabeth F. McInnes, Cheryl L. Scudamore, Cory F. Brayton

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.

Original languageEnglish (US)
Pages (from-to)133-168
Number of pages36
JournalILAR journal
Volume62
Issue number1-2
DOIs
StatePublished - 2021

Keywords

  • anatomy
  • animal model
  • bacteria
  • infectious disease
  • neoplasia
  • pathology
  • physiology
  • spontaneous
  • virus

ASJC Scopus subject areas

  • Medicine(all)

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