Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Ujjwal Neogi, Shwetha D. Rao, Irene Bontell, Jens Verheyen, Vasudev R. Rao, Sagar C. Gore, Neelesh Sonif, Anita Shet, Eugen Schülter, Maria L. Ekstrand, Amogne Wondwossen, Rolf Kaiser, Mallur S. Madhusudhan, Vinayaka R. Prasad, Anders Sonnerborg

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratioU17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Original languageEnglish (US)
Pages (from-to)2319-2322
Number of pages4
JournalAIDS
Volume28
Issue number15
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Neogi, U., Rao, S. D., Bontell, I., Verheyen, J., Rao, V. R., Gore, S. C., Sonif, N., Shet, A., Schülter, E., Ekstrand, M. L., Wondwossen, A., Kaiser, R., Madhusudhan, M. S., Prasad, V. R., & Sonnerborg, A. (2014). Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. AIDS, 28(15), 2319-2322. https://doi.org/10.1097/QAD.0000000000000419