TY - JOUR
T1 - Research agenda for preterm birth
T2 - Recommendations from the March of Dimes
AU - Green, Nancy S.
AU - Damus, Karla
AU - Simpson, Joe Leigh
AU - Iams, Jay
AU - Reece, E. Albert
AU - Hobel, Calvin J.
AU - Merkatz, Irwin R.
AU - Greene, Michael F.
AU - Schwarz, Richard H.
PY - 2005/9
Y1 - 2005/9
N2 - Preterm birth (PTB) is a common, serious, and costly health problem affecting nearly 1 in 8 births in the United States. Burdens from PTB are especially severe for the very preterm infant (<32 weeks' gestation), comprising 2% of all US births. Successful prevention needs to include newly focused and adequately funded research, incorporating new technologies and recognition that genetic, environmental, social, and behavioral factors interact in complex pathogeneses and multiple pathways leading to PTB. The March of Dimes Scientific Advisory Committee created this prioritized research agenda, which is aimed at garnering serious attention and expanding resources to make major inroads into the prevention of PTB, targeting six major, overlapping categories: epidemiology, genetics, disparities, inflammation, biologic stress, and clinical trials. Analogous to other common, complex disorders, progress in prevention will require incorporating multipronged risk reduction strategies that are based on sound scientific discovery, as well as on effective translation into clinical care.
AB - Preterm birth (PTB) is a common, serious, and costly health problem affecting nearly 1 in 8 births in the United States. Burdens from PTB are especially severe for the very preterm infant (<32 weeks' gestation), comprising 2% of all US births. Successful prevention needs to include newly focused and adequately funded research, incorporating new technologies and recognition that genetic, environmental, social, and behavioral factors interact in complex pathogeneses and multiple pathways leading to PTB. The March of Dimes Scientific Advisory Committee created this prioritized research agenda, which is aimed at garnering serious attention and expanding resources to make major inroads into the prevention of PTB, targeting six major, overlapping categories: epidemiology, genetics, disparities, inflammation, biologic stress, and clinical trials. Analogous to other common, complex disorders, progress in prevention will require incorporating multipronged risk reduction strategies that are based on sound scientific discovery, as well as on effective translation into clinical care.
KW - Common complex disorder
KW - Prematurity
KW - Research
KW - Very preterm
UR - http://www.scopus.com/inward/record.url?scp=24344464932&partnerID=8YFLogxK
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U2 - 10.1016/j.ajog.2005.02.106
DO - 10.1016/j.ajog.2005.02.106
M3 - Article
C2 - 16150253
AN - SCOPUS:24344464932
SN - 0002-9378
VL - 193
SP - 626
EP - 635
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -