Requirement of microfilaments in sorting of actin messenger RNA

Cynthia L. Sundell, Robert H. Singer

Research output: Contribution to journalArticle

204 Scopus citations


Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.

Original languageEnglish (US)
Pages (from-to)1275-1277
Number of pages3
Issue number5025
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • General

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