The neuroendocrine hormone PRL acts as a nase, cyclin B, and histone H3. Stimulation of L2 cells with progression factor during interleukin-2 (IL2) stimulated lym-PRL alone, however, induced only the expression of interferon phocyte proliferation. Since the sequential expression of cell regulatory factor-l. Depletion of PRL, through the use of an cycle regulated genes occurs during this process, we examined anti-PRL antiserum, inhibited IL2 driven proliferation and the the contribution of IL2 and PRL to specific RNA accumulation. expression of cyclin B and histone H3. These results demon-Stimulation of the cloned T cell line L2 with IL2 and PRL strate that PRL may regulate T cell proliferation by enhancing induced the sequential expression of interferon regulatory the expression of some genes necessary for entry into S-phase.
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