Reprogramming cellular signaling machinery using surface-modified carbon nanotubes

Yi Zhang, Ling Wu, Cuijuan Jiang, Bing Yan

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Nanoparticles, such as carbon nanotubes (CNTs), interact with cells and are easily internalized, causing various perturbations to cell functions. The mechanisms involved in such perturbations are investigated by a systematic approach that utilizes modified CNTs and various chemical-biological assays. Three modes of actions are (1) CNTs bind to different cell surface receptors and perturb different cell signaling pathways; (2) CNTs bind to a receptor with different affinity and, therefore, strengthen or weaken signals; (3) CNTs enter cells and bind to soluble signaling proteins involved in a signaling pathway. Understanding of such mechanisms not only clarifies how CNTs cause cytotoxicity but also demonstrates a useful method to modulate biological/toxicological activities of CNTs for their various industrial, biomedical, and consumer applications.

Original languageEnglish (US)
Pages (from-to)296-305
Number of pages10
JournalChemical research in toxicology
Issue number3
StatePublished - Mar 16 2015
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology


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