Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods

Sandra M. Meyers, Cornelia Laule, Irene M. Vavasour, Shannon H. Kolind, Burkhard Mädler, Roger Tam, Anthony L. Traboulsee, Jimmy Lee, David K.B. Li, Alex L. MacKay

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T2 distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method (R2=0.98) relative to the ROI method (R2=0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis.

Original languageEnglish (US)
Pages (from-to)1096-1103
Number of pages8
JournalMagnetic Resonance Imaging
Volume27
Issue number8
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Keywords

  • Myelin water
  • NNLS
  • T relaxation
  • Voxel-based analysis
  • White matter

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Meyers, S. M., Laule, C., Vavasour, I. M., Kolind, S. H., Mädler, B., Tam, R., Traboulsee, A. L., Lee, J., Li, D. K. B., & MacKay, A. L. (2009). Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods. Magnetic Resonance Imaging, 27(8), 1096-1103. https://doi.org/10.1016/j.mri.2009.02.001