Reproducibility of heart and blood pressure variability in patients with chronic obstructive pulmonary disease

Matthew N. Bartels, Sanja Jelic, John M. Gonzalez, Woojin Kim, Ronald E. De Meersman

Research output: Contribution to journalArticle

13 Scopus citations


Wide variations in respiratory rate and hypoxic stimulation of chemoreceptors may produce unreliable autonomic results in patients with COPD. We studied the reproducibility of two consecutive measurements of heart rate variability (HRV) and blood pressure variability (BPV) by time frequency analysis in patients with COPD while controlling respiratory rate and oxygen hemoglobin saturation (SaO2). Reproducibility was assessed by paired t-tests and correlation analyses between repeated measures. Correlation analyses of the log transformed low (LF) and high frequency (HF) HRV were x̄ 11.5±1.1 in measurement A and x̄ 11.5±1.0 in measurement B (r = 0.89, p < 0.0001), and x̄ 10.5±1.1 in measurement A and x̄ 10.6±1.1 in measurement B (r = 0.89, p < 0.0001) respectively. The log transformed LF and HF BPV were x̄ 4.9±1.3 in measurement A and ̄ 5.3±0.9 in measurement B (r = 0.70, p < 0.0002), and x̄ 6.4±1.3 in measurement A and 6.6±1.2 in measurement B (R = 0.71 p < 0.0001) respectively. In conclusion, time frequency analysis of HRV and BPV is reproducible and reliable in patients with COPD while controlling their respiratory rate and oxygen hemoglobin saturation. Reproducibility of these measurements may allow for a non-invasive evaluation of autonomie tone in response to treatments in COPD patients.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalClinical Autonomic Research
Issue number3
Publication statusPublished - Jun 2004
Externally publishedYes



  • Blood pressure variability
  • COPD
  • Heart rate variability
  • Time frequency analysis

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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