Reproducibility of electrophysiologic testing during antiarrhythmic therapy for ventricular arrhythmias secondary to coronary artery disease

Kevin J. Ferrick, Joshua Luce, Sara Miller, Anthony D. Mercando, Soo G. Kim, James A. Roth, John Devens Fisher

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Although electrophysiologic studies are often used to assess antiarrhythmic drug efficacy in patients with ventricular tachycardia (VT), the reproducibility of these studies during therapy has not been definitively established. Confirmation studies were performed during drug therapy in 64 patients (51 men, mean age 63 years) with sustained ventricular arrhythmias induced during initial study to assess the reproducibility of drug effect. All patients had coronary artery disease. The stimulation protocol used included the serial introduction of up to 3 premature ventricular stimuli during sinus rhythm and with ventricular pacing at 2 pacing rates. Rapid ventricular pacing techniques were also used. Antiarrhythmic drug efficacy was confirmed in 77% of patients. Sustained VT was induced at repeat electrophysiologic study in 19% of patients during antiarrhythmic therapy that was previously thought to be effective. In summary, electrophysiologic study results during antiarrhythmic therapy exhibit significant day-to-day variability. Sustained VT can be induced during antiarrhythmic therapy that was previously defined as effective by programmed stimulation in a substantial number of patients.

Original languageEnglish (US)
Pages (from-to)1296-1299
Number of pages4
JournalThe American Journal of Cardiology
Volume69
Issue number16
DOIs
StatePublished - May 15 1992

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Cardiac Arrhythmias
Coronary Artery Disease
Ventricular Tachycardia
Anti-Arrhythmia Agents
Therapeutics
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Reproducibility of electrophysiologic testing during antiarrhythmic therapy for ventricular arrhythmias secondary to coronary artery disease. / Ferrick, Kevin J.; Luce, Joshua; Miller, Sara; Mercando, Anthony D.; Kim, Soo G.; Roth, James A.; Fisher, John Devens.

In: The American Journal of Cardiology, Vol. 69, No. 16, 15.05.1992, p. 1296-1299.

Research output: Contribution to journalArticle

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AU - Luce, Joshua

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AU - Kim, Soo G.

AU - Roth, James A.

AU - Fisher, John Devens

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AB - Although electrophysiologic studies are often used to assess antiarrhythmic drug efficacy in patients with ventricular tachycardia (VT), the reproducibility of these studies during therapy has not been definitively established. Confirmation studies were performed during drug therapy in 64 patients (51 men, mean age 63 years) with sustained ventricular arrhythmias induced during initial study to assess the reproducibility of drug effect. All patients had coronary artery disease. The stimulation protocol used included the serial introduction of up to 3 premature ventricular stimuli during sinus rhythm and with ventricular pacing at 2 pacing rates. Rapid ventricular pacing techniques were also used. Antiarrhythmic drug efficacy was confirmed in 77% of patients. Sustained VT was induced at repeat electrophysiologic study in 19% of patients during antiarrhythmic therapy that was previously thought to be effective. In summary, electrophysiologic study results during antiarrhythmic therapy exhibit significant day-to-day variability. Sustained VT can be induced during antiarrhythmic therapy that was previously defined as effective by programmed stimulation in a substantial number of patients.

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