Reported intake of selected micronutrients and risk of colorectal cancer: Results from a large population-based case-control study in Newfoundland, Labrador and Ontario, Canada

Zhuoyu Sun, Yun Zhu, Peizhong Peter Wang, Barbara Roebothan, Jing Zhao, Jinhui Zhao, Elizabeth Dicks, Michelle Cotterchio, Sharon Buehler, Peter T. Campbell, John R. Mclaughlin, Patrick S. Parfrey

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Aim: The impact of micronutrient intake and colorectal cancer (CRC) risk is poorly understood. The objective of this study was to evaluate the associations of selected micronutrients with risk of incident CRC in study participants from Newfoundland, Labrador (NL) and Ontario (ON), Canada. Materials and Methods: We conducted a population-based study among 1760 case participants and 2481 age- and sex-matched control participants. Information on diet and other lifestyle factors were measured using a food frequency questionnaire and a personal history questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, controlling for covariables. Results: Highest compared to lowest quartile intakes of certain micronutrients were associated with lower risk of CRC, including: calcium (from food and supplements (FS), OR=059; 95% CI=O.45-0.77, and from food only (FO): OR=0.76, 95% CI=0.59-0.97), vitamin C (FS:OR=0.67; 95%CI:0.51-0.88), vitamin D (FS: OR=0.73; 95% CI: 0.57-0.94, FO: OR=0.79, 95% CI=0.62-1.00), riboflavin (FS: OR=0.61; 95% CI=0.47-0.78, and folate (FS: OR=0.72; 95% CI=0.56-0.92). Higher risk of CRC was observed for iron intake (highest versus lowest quintiles: OR=0.34, 95% CI=1.01-1.78). Conclusion: This study presents evidence that dietary intake of calcium, vitamin D, vitamin C, riboflavin and folate are associated with a lower risk of incident CRC and that dietary intake of iron may be associated with a higher risk of the disease.

Original languageEnglish (US)
Pages (from-to)687-696
Number of pages10
JournalAnticancer Research
Volume32
Issue number2
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • Canada
  • Case-control study
  • Colorectal cancer
  • Iron intake
  • Micronutrients
  • Vitamin C intake
  • Vitamin D intake, riboflavin intake, folate intake

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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