TY - JOUR
T1 - Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes
AU - Demetriou, Achilles A.
AU - Whiting, James F.
AU - Feldman, David
AU - Levenson, Stanley M.
AU - Chowdhury, Namita Roy
AU - Moscioni, Albert D.
AU - Kram, Michael
AU - Chowdhury, Jayanta Roy
PY - 1986
Y1 - 1986
N2 - Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.
AB - Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.
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U2 - 10.1126/science.2426782
DO - 10.1126/science.2426782
M3 - Article
C2 - 2426782
AN - SCOPUS:0022460518
SN - 0036-8075
VL - 233
SP - 1190
EP - 1192
JO - Science
JF - Science
IS - 4769
ER -