Renal transplantation in baboons under FK 506

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial.

Original languageEnglish (US)
Pages (from-to)444-451
Number of pages8
JournalSurgery
Volume106
Issue number2
StatePublished - Aug 1989
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Surgery

Cite this

Renal transplantation in baboons under FK 506. / Todo, Satoru; Demetris, Anthony; Ueda, Yuji; Imventarza, Oscar; Cadoff, Evan; Zeevi, Andriana; Starzl, Thomas E.

In: Surgery, Vol. 106, No. 2, 08.1989, p. 444-451.

Research output: Contribution to journalArticle