Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults

Brandilyn A. Peters, Megan N. Hall, Xinhua Liu, Vesna Slavkovich, Vesna Ilievski, Shafiul Alam, Abu B. Siddique, Tariqul Islam, Joseph H. Graziano, Mary V. Gamble

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. Objectives: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. Methods: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. Results: In covariate-adjusted linear models, a 1ml/min/1.73m2 increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. Conclusions: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalEnvironmental Research
Volume143
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Fingerprint

Methylation
methylation
Arsenic
arsenic
Glomerular Filtration Rate
Kidney
Blood
blood
Metabolites
metabolite
Dynamic mechanical analysis
urine
indicator
Urine
Cacodylic Acid
Cystatin C
acid
rate
indium arsenide
excretion

Keywords

  • Arsenic
  • Bangladesh
  • Glomerular filtration rate
  • Kidney
  • Methylation

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. / Peters, Brandilyn A.; Hall, Megan N.; Liu, Xinhua; Slavkovich, Vesna; Ilievski, Vesna; Alam, Shafiul; Siddique, Abu B.; Islam, Tariqul; Graziano, Joseph H.; Gamble, Mary V.

In: Environmental Research, Vol. 143, 01.11.2015, p. 123-130.

Research output: Contribution to journalArticle

Peters, BA, Hall, MN, Liu, X, Slavkovich, V, Ilievski, V, Alam, S, Siddique, AB, Islam, T, Graziano, JH & Gamble, MV 2015, 'Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults', Environmental Research, vol. 143, pp. 123-130. https://doi.org/10.1016/j.envres.2015.10.001
Peters, Brandilyn A. ; Hall, Megan N. ; Liu, Xinhua ; Slavkovich, Vesna ; Ilievski, Vesna ; Alam, Shafiul ; Siddique, Abu B. ; Islam, Tariqul ; Graziano, Joseph H. ; Gamble, Mary V. / Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. In: Environmental Research. 2015 ; Vol. 143. pp. 123-130.
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abstract = "Background: Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As ({\%}InAs), monomethylarsonic acid ({\%}MMA), and dimethylarsinic acid ({\%}DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. Objectives: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and {\%}As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood {\%}As metabolites with respective urinary {\%}As metabolites. Methods: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. Results: In covariate-adjusted linear models, a 1ml/min/1.73m2 increase in eGFR was associated with a 0.39{\%} increase in urinary {\%}InAs (p<0.0001) and a mean decrease in urinary {\%}DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood {\%}InAs and decreased blood {\%}DMA did not reach statistical significance. eGFR was not associated with urinary or blood {\%}MMA in covariate-adjusted models. For a given increase in blood {\%}InAs, the increase in urinary {\%}InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for {\%}MMA or {\%}DMA. Conclusions: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary {\%}InAs) may be detrimental to renal function.",
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author = "Peters, {Brandilyn A.} and Hall, {Megan N.} and Xinhua Liu and Vesna Slavkovich and Vesna Ilievski and Shafiul Alam and Siddique, {Abu B.} and Tariqul Islam and Graziano, {Joseph H.} and Gamble, {Mary V.}",
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T1 - Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults

AU - Peters, Brandilyn A.

AU - Hall, Megan N.

AU - Liu, Xinhua

AU - Slavkovich, Vesna

AU - Ilievski, Vesna

AU - Alam, Shafiul

AU - Siddique, Abu B.

AU - Islam, Tariqul

AU - Graziano, Joseph H.

AU - Gamble, Mary V.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. Objectives: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. Methods: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. Results: In covariate-adjusted linear models, a 1ml/min/1.73m2 increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. Conclusions: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.

AB - Background: Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. Objectives: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. Methods: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. Results: In covariate-adjusted linear models, a 1ml/min/1.73m2 increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. Conclusions: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.

KW - Arsenic

KW - Bangladesh

KW - Glomerular filtration rate

KW - Kidney

KW - Methylation

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