Renal Function After Pediatric Intestinal Transplant

T. Ueno, T. Kato, J. Gaynor, M. Velasco, G. Selvaggi, G. Zilleruelo, G. McLaughlin, E. Hernandez, J. Thompson, A. Tzakis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Data were analyzed from 44 patients who survived more than 2 years after intestinal transplantation performed between 1994 and 2002. Median age was 1.7 years. Tacrolimus level was defined as average tacrolimus level over 6 months. Kidney function was evaluated using a 6-month average serum creatinine. Glomerular filtration rate (GFR) was calculated with the Schwartz formula. The procedures were: isolated intestinal transplantation (n = 11), liver and intestinal transplantation (n = 9), multivisceral transplantation (n = 22), and modified multivisceral transplantation (n = 2). Forty-four patients were followed for a mean of 3.6 years on tacrolimus. Tacrolimus levels ranged between 3.5 and 19.9 ng/mL (median 14.6 ng/mL) at 0 to 6 months and 6.0 to 18.9 ng/mL (median 13.2 ng/mL) at 0 to 12 months. Pretransplant kidney function as mean GFR was 138 ± 42 mL/min/1.73 m2 (n = 44), posttransplant kidney function at 18 to 24 month as mean GFR was 102 ± 35 mL/min/1.73 m2 (n = 44), a value that was 81% of the pretransplant GFR (P < .0001). In an analysis of tacrolimus level versus renal function, a value greater than 13.5 ng/mL during the first 12 months was a significant predictor for impaired renal function at 2 years after transplantation (defined as average GFR less than 90 mL/min/1.73 m2 at 18 to 24 months; P = .001). Only age among age, sex, diagnosis, transplant type, and rejection episodes showed a correlation with renal function. Renal function dropped significantly at 2 years after pediatric intestinal transplantation to 81% of the pretransplantation value. Tacrolimus level for the first 12 months seemed to predict subsequent development of renal impairment at 2 years.

Original languageEnglish (US)
Pages (from-to)1759-1761
Number of pages3
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Ueno, T., Kato, T., Gaynor, J., Velasco, M., Selvaggi, G., Zilleruelo, G., McLaughlin, G., Hernandez, E., Thompson, J., & Tzakis, A. (2006). Renal Function After Pediatric Intestinal Transplant. Transplantation Proceedings, 38(6), 1759-1761. https://doi.org/10.1016/j.transproceed.2006.05.026