Renal development in the fetus and premature infant

Stacy Rosenblum, Abhijeet Pal, Kimberly J. Reidy

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Congenital abnormalities of the kidney and urinary tract (CAKUT) are one of the leading congenital defects to be identified on prenatal ultrasound. CAKUT represent a broad spectrum of abnormalities, from transient hydronephrosis to severe bilateral renal agenesis. CAKUT are a major contributor to chronic and end stage kidney disease (CKD/ESKD) in children. Prenatal imaging is useful to identify CAKUT, but will not detect all defects. Both genetic abnormalities and the fetal environment contribute to CAKUT. Monogenic gene mutations identified in human CAKUT have advanced our understanding of molecular mechanisms of renal development. Low nephron number and solitary kidneys are associated with increased risk of adult onset CKD and ESKD. Premature and low birth weight infants represent a high risk population for low nephron number. Additional research is needed to identify biomarkers and appropriate follow-up of premature and low birth weight infants into adulthood.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalSeminars in Fetal and Neonatal Medicine
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2017

Fingerprint

Premature Infants
Fetus
Urinary Tract
Kidney
Nephrons
Premature Birth
Low Birth Weight Infant
Hydronephrosis
Chronic Kidney Failure
Biomarkers
Mutation
Research
Population
Genes

Keywords

  • Congenital abnormalities of the kidney and urinary tract (CAKUT)
  • Fetal ultrasonography
  • Hydronephrosis
  • Prematurity
  • Renal development
  • Urinary tract obstruction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Renal development in the fetus and premature infant. / Rosenblum, Stacy; Pal, Abhijeet; Reidy, Kimberly J.

In: Seminars in Fetal and Neonatal Medicine, Vol. 22, No. 2, 01.04.2017, p. 58-66.

Research output: Contribution to journalReview article

Rosenblum, Stacy ; Pal, Abhijeet ; Reidy, Kimberly J. / Renal development in the fetus and premature infant. In: Seminars in Fetal and Neonatal Medicine. 2017 ; Vol. 22, No. 2. pp. 58-66.
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