Remyelination in multiple sclerosis with peripheral type myelin

N. R. Ghatak, A. Hirano, Y. Doron, H. M. Zimmerman

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Unusually large areas of remyelination occurred in demyelinated plaques within the spinal cord of a patient with long standing multiple sclerosis (MS). The regenerated myelin was indistinguishable from that of the peripheral nerves by optical and electron microscopy. The myelin forming cells within the spinal cord, morphologically identical to the Schwann cells, could be traced to the spinal nerve roots. At the periphery of the remyelinated zones, astrocytic processes were present adjacent to the regenerated peripheral type myelinated fibers similar to those normally seen in the nerve roots close to the spinal cord. In addition, Rosenthal fibers were frequently seen in such zones. There was no appreciable clinical improvement in this patient attributable to the remyelination. The mechanism of such focal remyelination in this otherwise typical case of MS remains obscure.

Original languageEnglish (US)
Pages (from-to)262-267
Number of pages6
JournalArchives of Neurology
Volume29
Issue number4
StatePublished - 1973

Fingerprint

Myelin Sheath
Multiple Sclerosis
Spinal Cord
Spinal Nerve Roots
Schwann Cells
Peripheral Nerves
Electron Microscopy
Nerve
Cord
Fiber
Cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ghatak, N. R., Hirano, A., Doron, Y., & Zimmerman, H. M. (1973). Remyelination in multiple sclerosis with peripheral type myelin. Archives of Neurology, 29(4), 262-267.

Remyelination in multiple sclerosis with peripheral type myelin. / Ghatak, N. R.; Hirano, A.; Doron, Y.; Zimmerman, H. M.

In: Archives of Neurology, Vol. 29, No. 4, 1973, p. 262-267.

Research output: Contribution to journalArticle

Ghatak, NR, Hirano, A, Doron, Y & Zimmerman, HM 1973, 'Remyelination in multiple sclerosis with peripheral type myelin', Archives of Neurology, vol. 29, no. 4, pp. 262-267.
Ghatak NR, Hirano A, Doron Y, Zimmerman HM. Remyelination in multiple sclerosis with peripheral type myelin. Archives of Neurology. 1973;29(4):262-267.
Ghatak, N. R. ; Hirano, A. ; Doron, Y. ; Zimmerman, H. M. / Remyelination in multiple sclerosis with peripheral type myelin. In: Archives of Neurology. 1973 ; Vol. 29, No. 4. pp. 262-267.
@article{fe42cb32e1694362b8dde38c88b76ed8,
title = "Remyelination in multiple sclerosis with peripheral type myelin",
abstract = "Unusually large areas of remyelination occurred in demyelinated plaques within the spinal cord of a patient with long standing multiple sclerosis (MS). The regenerated myelin was indistinguishable from that of the peripheral nerves by optical and electron microscopy. The myelin forming cells within the spinal cord, morphologically identical to the Schwann cells, could be traced to the spinal nerve roots. At the periphery of the remyelinated zones, astrocytic processes were present adjacent to the regenerated peripheral type myelinated fibers similar to those normally seen in the nerve roots close to the spinal cord. In addition, Rosenthal fibers were frequently seen in such zones. There was no appreciable clinical improvement in this patient attributable to the remyelination. The mechanism of such focal remyelination in this otherwise typical case of MS remains obscure.",
author = "Ghatak, {N. R.} and A. Hirano and Y. Doron and Zimmerman, {H. M.}",
year = "1973",
language = "English (US)",
volume = "29",
pages = "262--267",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Remyelination in multiple sclerosis with peripheral type myelin

AU - Ghatak, N. R.

AU - Hirano, A.

AU - Doron, Y.

AU - Zimmerman, H. M.

PY - 1973

Y1 - 1973

N2 - Unusually large areas of remyelination occurred in demyelinated plaques within the spinal cord of a patient with long standing multiple sclerosis (MS). The regenerated myelin was indistinguishable from that of the peripheral nerves by optical and electron microscopy. The myelin forming cells within the spinal cord, morphologically identical to the Schwann cells, could be traced to the spinal nerve roots. At the periphery of the remyelinated zones, astrocytic processes were present adjacent to the regenerated peripheral type myelinated fibers similar to those normally seen in the nerve roots close to the spinal cord. In addition, Rosenthal fibers were frequently seen in such zones. There was no appreciable clinical improvement in this patient attributable to the remyelination. The mechanism of such focal remyelination in this otherwise typical case of MS remains obscure.

AB - Unusually large areas of remyelination occurred in demyelinated plaques within the spinal cord of a patient with long standing multiple sclerosis (MS). The regenerated myelin was indistinguishable from that of the peripheral nerves by optical and electron microscopy. The myelin forming cells within the spinal cord, morphologically identical to the Schwann cells, could be traced to the spinal nerve roots. At the periphery of the remyelinated zones, astrocytic processes were present adjacent to the regenerated peripheral type myelinated fibers similar to those normally seen in the nerve roots close to the spinal cord. In addition, Rosenthal fibers were frequently seen in such zones. There was no appreciable clinical improvement in this patient attributable to the remyelination. The mechanism of such focal remyelination in this otherwise typical case of MS remains obscure.

UR - http://www.scopus.com/inward/record.url?scp=0015808150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015808150&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 262

EP - 267

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 4

ER -