Removal of visceral fat prevents insulin resistance and glucose intolerance of aging

An adipokine-mediated process?

Ilan Gabriely, Xiao Hui Ma, Xiao Man Yang, Gil Atzmon, Michael W. Rajala, Anders H. Berg, Phillip Scherer, Luciano Rossetti, Nir Barzilai

Research output: Contribution to journalArticle

403 Citations (Scopus)

Abstract

Age-dependent changes in insulin action and body fat distribution are risk factors for the development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored insulin action, glucose tolerance, and the expression of adipo-derived peptides after surgical removal of VF in aging (20-month-old) F344/Brown Norway (FBN) and in Zucker Diabetic Fatty (ZDF) rats. As expected, peripheral and hepatic insulin action were markedly impaired in aging FBN rats, and extraction of VF (accounting for ∼18% of their total body fat) was sufficient to restore peripheral and hepatic insulin action to the levels of young rats. When examined at the mechanistic level, removal of VF in ZDF rats prevented the progressive decrease in insulin action and delayed the onset of diabetes, but VF extraction did not alter plasma free fatty acid levels. However, the expression of tumor necrosis factor-α and leptin in subcutaneous (SC) adipose tissue were markedly decreased after VF removal (by approximately three- and twofold, respectively). Finally, extracted VF retained ∼15-fold higher resistin mRNA compared with SC fat. Our data suggest that insulin resistance and the development of diabetes can be significantly reduced in aging rats by preventing the age-dependent accumulation of VF. This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)2951-2958
Number of pages8
JournalDiabetes
Volume51
Issue number10
StatePublished - Oct 1 2002

Fingerprint

Adipokines
Glucose Intolerance
Intra-Abdominal Fat
Insulin Resistance
Insulin
Subcutaneous Fat
Type 2 Diabetes Mellitus
Resistin
Body Fat Distribution
Liver
Norway
Leptin
Nonesterified Fatty Acids
Adipose Tissue
Tumor Necrosis Factor-alpha
Glucose
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Gabriely, I., Ma, X. H., Yang, X. M., Atzmon, G., Rajala, M. W., Berg, A. H., ... Barzilai, N. (2002). Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: An adipokine-mediated process? Diabetes, 51(10), 2951-2958.

Removal of visceral fat prevents insulin resistance and glucose intolerance of aging : An adipokine-mediated process? / Gabriely, Ilan; Ma, Xiao Hui; Yang, Xiao Man; Atzmon, Gil; Rajala, Michael W.; Berg, Anders H.; Scherer, Phillip; Rossetti, Luciano; Barzilai, Nir.

In: Diabetes, Vol. 51, No. 10, 01.10.2002, p. 2951-2958.

Research output: Contribution to journalArticle

Gabriely, I, Ma, XH, Yang, XM, Atzmon, G, Rajala, MW, Berg, AH, Scherer, P, Rossetti, L & Barzilai, N 2002, 'Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: An adipokine-mediated process?', Diabetes, vol. 51, no. 10, pp. 2951-2958.
Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: An adipokine-mediated process? Diabetes. 2002 Oct 1;51(10):2951-2958.
Gabriely, Ilan ; Ma, Xiao Hui ; Yang, Xiao Man ; Atzmon, Gil ; Rajala, Michael W. ; Berg, Anders H. ; Scherer, Phillip ; Rossetti, Luciano ; Barzilai, Nir. / Removal of visceral fat prevents insulin resistance and glucose intolerance of aging : An adipokine-mediated process?. In: Diabetes. 2002 ; Vol. 51, No. 10. pp. 2951-2958.
@article{b71cf1a328ad4df68f7f23f92e135ab0,
title = "Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: An adipokine-mediated process?",
abstract = "Age-dependent changes in insulin action and body fat distribution are risk factors for the development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored insulin action, glucose tolerance, and the expression of adipo-derived peptides after surgical removal of VF in aging (20-month-old) F344/Brown Norway (FBN) and in Zucker Diabetic Fatty (ZDF) rats. As expected, peripheral and hepatic insulin action were markedly impaired in aging FBN rats, and extraction of VF (accounting for ∼18{\%} of their total body fat) was sufficient to restore peripheral and hepatic insulin action to the levels of young rats. When examined at the mechanistic level, removal of VF in ZDF rats prevented the progressive decrease in insulin action and delayed the onset of diabetes, but VF extraction did not alter plasma free fatty acid levels. However, the expression of tumor necrosis factor-α and leptin in subcutaneous (SC) adipose tissue were markedly decreased after VF removal (by approximately three- and twofold, respectively). Finally, extracted VF retained ∼15-fold higher resistin mRNA compared with SC fat. Our data suggest that insulin resistance and the development of diabetes can be significantly reduced in aging rats by preventing the age-dependent accumulation of VF. This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome.",
author = "Ilan Gabriely and Ma, {Xiao Hui} and Yang, {Xiao Man} and Gil Atzmon and Rajala, {Michael W.} and Berg, {Anders H.} and Phillip Scherer and Luciano Rossetti and Nir Barzilai",
year = "2002",
month = "10",
day = "1",
language = "English (US)",
volume = "51",
pages = "2951--2958",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "10",

}

TY - JOUR

T1 - Removal of visceral fat prevents insulin resistance and glucose intolerance of aging

T2 - An adipokine-mediated process?

AU - Gabriely, Ilan

AU - Ma, Xiao Hui

AU - Yang, Xiao Man

AU - Atzmon, Gil

AU - Rajala, Michael W.

AU - Berg, Anders H.

AU - Scherer, Phillip

AU - Rossetti, Luciano

AU - Barzilai, Nir

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Age-dependent changes in insulin action and body fat distribution are risk factors for the development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored insulin action, glucose tolerance, and the expression of adipo-derived peptides after surgical removal of VF in aging (20-month-old) F344/Brown Norway (FBN) and in Zucker Diabetic Fatty (ZDF) rats. As expected, peripheral and hepatic insulin action were markedly impaired in aging FBN rats, and extraction of VF (accounting for ∼18% of their total body fat) was sufficient to restore peripheral and hepatic insulin action to the levels of young rats. When examined at the mechanistic level, removal of VF in ZDF rats prevented the progressive decrease in insulin action and delayed the onset of diabetes, but VF extraction did not alter plasma free fatty acid levels. However, the expression of tumor necrosis factor-α and leptin in subcutaneous (SC) adipose tissue were markedly decreased after VF removal (by approximately three- and twofold, respectively). Finally, extracted VF retained ∼15-fold higher resistin mRNA compared with SC fat. Our data suggest that insulin resistance and the development of diabetes can be significantly reduced in aging rats by preventing the age-dependent accumulation of VF. This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome.

AB - Age-dependent changes in insulin action and body fat distribution are risk factors for the development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored insulin action, glucose tolerance, and the expression of adipo-derived peptides after surgical removal of VF in aging (20-month-old) F344/Brown Norway (FBN) and in Zucker Diabetic Fatty (ZDF) rats. As expected, peripheral and hepatic insulin action were markedly impaired in aging FBN rats, and extraction of VF (accounting for ∼18% of their total body fat) was sufficient to restore peripheral and hepatic insulin action to the levels of young rats. When examined at the mechanistic level, removal of VF in ZDF rats prevented the progressive decrease in insulin action and delayed the onset of diabetes, but VF extraction did not alter plasma free fatty acid levels. However, the expression of tumor necrosis factor-α and leptin in subcutaneous (SC) adipose tissue were markedly decreased after VF removal (by approximately three- and twofold, respectively). Finally, extracted VF retained ∼15-fold higher resistin mRNA compared with SC fat. Our data suggest that insulin resistance and the development of diabetes can be significantly reduced in aging rats by preventing the age-dependent accumulation of VF. This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0036787345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036787345&partnerID=8YFLogxK

M3 - Article

VL - 51

SP - 2951

EP - 2958

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 10

ER -