Relevance of focal osseous uptake on FDG PET with or without CT changes in oncology patients

Gunjan Garg, Raphaella DaSilva, Mimi Kim, Charito Love, Tony Abraham

Research output: Contribution to journalArticle

Abstract

Objective To assess significance of focal FDG uptake in osseous structures, with and without CT correlate, in patients undergoing FDG PET/CT for oncological indications. Methods 57 patients with focally increased FDG activity in bones and a definite follow up were included. Results 85.2% of lesions without changes were found to be malignant. Sensitivity and PPV of a CT correlate in metastatic lesions was expectedly high, 62.9% and 86.7% respectively, however, the NPV was only 14.8%. Conclusion Osseous foci are valuable in predicting metastatic disease even in the absence of low dose CT correlate.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalClinical Imaging
Volume42
DOIs
StatePublished - Mar 1 2017

Fingerprint

Bone and Bones

Keywords

  • Bone metastases
  • CT correlate
  • FDG PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Relevance of focal osseous uptake on FDG PET with or without CT changes in oncology patients. / Garg, Gunjan; DaSilva, Raphaella; Kim, Mimi; Love, Charito; Abraham, Tony.

In: Clinical Imaging, Vol. 42, 01.03.2017, p. 138-146.

Research output: Contribution to journalArticle

@article{0db2d41bc9d246f18fba2a67d5cba903,
title = "Relevance of focal osseous uptake on FDG PET with or without CT changes in oncology patients",
abstract = "Objective To assess significance of focal FDG uptake in osseous structures, with and without CT correlate, in patients undergoing FDG PET/CT for oncological indications. Methods 57 patients with focally increased FDG activity in bones and a definite follow up were included. Results 85.2{\%} of lesions without changes were found to be malignant. Sensitivity and PPV of a CT correlate in metastatic lesions was expectedly high, 62.9{\%} and 86.7{\%} respectively, however, the NPV was only 14.8{\%}. Conclusion Osseous foci are valuable in predicting metastatic disease even in the absence of low dose CT correlate.",
keywords = "Bone metastases, CT correlate, FDG PET",
author = "Gunjan Garg and Raphaella DaSilva and Mimi Kim and Charito Love and Tony Abraham",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.clinimag.2016.12.003",
language = "English (US)",
volume = "42",
pages = "138--146",
journal = "Clinical Imaging",
issn = "0899-7071",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Relevance of focal osseous uptake on FDG PET with or without CT changes in oncology patients

AU - Garg, Gunjan

AU - DaSilva, Raphaella

AU - Kim, Mimi

AU - Love, Charito

AU - Abraham, Tony

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective To assess significance of focal FDG uptake in osseous structures, with and without CT correlate, in patients undergoing FDG PET/CT for oncological indications. Methods 57 patients with focally increased FDG activity in bones and a definite follow up were included. Results 85.2% of lesions without changes were found to be malignant. Sensitivity and PPV of a CT correlate in metastatic lesions was expectedly high, 62.9% and 86.7% respectively, however, the NPV was only 14.8%. Conclusion Osseous foci are valuable in predicting metastatic disease even in the absence of low dose CT correlate.

AB - Objective To assess significance of focal FDG uptake in osseous structures, with and without CT correlate, in patients undergoing FDG PET/CT for oncological indications. Methods 57 patients with focally increased FDG activity in bones and a definite follow up were included. Results 85.2% of lesions without changes were found to be malignant. Sensitivity and PPV of a CT correlate in metastatic lesions was expectedly high, 62.9% and 86.7% respectively, however, the NPV was only 14.8%. Conclusion Osseous foci are valuable in predicting metastatic disease even in the absence of low dose CT correlate.

KW - Bone metastases

KW - CT correlate

KW - FDG PET

UR - http://www.scopus.com/inward/record.url?scp=85003876164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85003876164&partnerID=8YFLogxK

U2 - 10.1016/j.clinimag.2016.12.003

DO - 10.1016/j.clinimag.2016.12.003

M3 - Article

VL - 42

SP - 138

EP - 146

JO - Clinical Imaging

JF - Clinical Imaging

SN - 0899-7071

ER -