Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the women's interagency HIV study of HIV-infected and uninfected women in the United States

Janice B. Schwartz, Kelly L. Moore, Michael Yin, Anjali Sharma, Dan Merenstein, Talat Islam, Elizabeth T. Golub, Phyllis C. Tien, Oluwatoyin M. Adeyemi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Relationships between vitamin D, lipids, HIV infection, and HIV treatment (±antiretroviral therapy [ART]) were investigated with Women's Interagency HIV Study data (n = 1758 middle-aged women) using multivariable regression. Sixty-three percent of women had vitamin D deficiency. Median 25-hydroxyvitamin D (25-OH vitamin D) was highest in HIV-infected + ART-treated women (17 ng/mL; P <.001) and was the same in HIV-uninfected or HIV-infected women without ART (14 ng/mL). Vitamin D levels were lower if efavirenz (EFV) was included in ART (15 versus 19 ng/mL; P <.001). The most common lipid abnormality was high triglycerides (≥ 200 mg/dL) in HIV-infected + ART-treated women (13% versus 7% of HIV-infected without ART and 5% of HIV-uninfected; P <.001), with a positive relationship between 25-OH vitamin D and triglycerides (95% confidence interval 0.32-1.69; P <.01). No relationships between 25-OH vitamin D and cholesterol were detected. Vitamin D deficiency is common irrespective of HIV status but influenced by HIV treatment. Similarly, vitamin D levels were positively related to triglycerides only in ART-treated HIV-infected women and unrelated to cholesterol.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • 25-OH vitamin D
  • HIV infected
  • HIV uninfected
  • LDL cholesterol
  • WIHS
  • cholesterol
  • lipids
  • triglycerides
  • vitamin D

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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