Relationship of maternal creatinine to first neonatal creatinine in infants <30 weeks gestation

Objective:To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors.Study Design:In this 51/2-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t-test. Linear regression for correlated outcomes employing generalized estimating equations was used to examine neonatal Cr as a function of antenatal maternal Cr and potential confounders.Result:A total of 157 neonates of 124 mothers met study criteria. Neonatal Cr values in the first 24 h of life were significantly higher than antenatal maternal values. Linear regression modeling showed that maternal Cr, neonatal lactate, hypoxic-ischemic villous changes on placental pathology and multiple gestation were each significant determinants of the first neonatal Cr.Conclusion:No neonatal Cr was less than its paired maternal value. Maternal Cr, neonatal lactate, hypoxic-ischemic villous changes in the placenta and multiple gestation were each significantly associated with neonatal Cr.