Relationship of maternal creatinine to first neonatal creatinine in infants <30 weeks gestation

A. S. Weintraub, A. Carey, J. Connors, V. Blanco, R. S. Green

Research output: Contribution to journalArticle

3 Scopus citations


Objective:To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors.Study Design:In this 51/2-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t-test. Linear regression for correlated outcomes employing generalized estimating equations was used to examine neonatal Cr as a function of antenatal maternal Cr and potential confounders.Result:A total of 157 neonates of 124 mothers met study criteria. Neonatal Cr values in the first 24 h of life were significantly higher than antenatal maternal values. Linear regression modeling showed that maternal Cr, neonatal lactate, hypoxic-ischemic villous changes on placental pathology and multiple gestation were each significant determinants of the first neonatal Cr.Conclusion:No neonatal Cr was less than its paired maternal value. Maternal Cr, neonatal lactate, hypoxic-ischemic villous changes in the placenta and multiple gestation were each significantly associated with neonatal Cr.

Original languageEnglish (US)
Pages (from-to)401-404
Number of pages4
JournalJournal of Perinatology
Issue number6
Publication statusPublished - Jun 28 2015
Externally publishedYes


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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