Relationship between urine dichlorophenol levels and asthma morbidity

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Chlorinated phenols are associated with atopic conditions, but it is not known whether they are associated with wheeze or asthma and whether atopy is involved in these associations. Objectives To test the association between urine levels of 2 dichlorophenols (2,4- and 2,5-dichlorophenols) and asthma morbidity in atopic and nonatopic wheezers and between total serum immunoglobulin E (IgE) levels. Methods Data from a sample of 2,125 participants at least 6 years old from the US National Health and Nutrition Examination Survey 2005 to 2006 were analyzed. Asthma morbidity data were available for those participants who reported wheezing in the past year ("wheezers"; n = 250). This subsample was categorized as atopic or nonatopic. Results Atopic wheezers with higher 2,5-dichlorophenol levels were more frequently diagnosed with asthma by a physician (odds ratio [OR] 4.7 for highest vs lowest tertile, P <.001), required more prescriptions for asthma medications (OR 2.2, P =.046), and reported more exercise-induced wheezing (OR 5.8, P =.045) than atopic wheezers with low dichlorophenol levels. Atopic wheezers with higher 2,5- or 2,4-dichloropheonol levels also were more likely to miss work or school because of wheezing (OR 10.0, P <.001; OR 11.4, P <.01, respectively). In contrast, in nonatopic wheezers, there were no significant associations between dichlorophenol levels and asthma morbidity measurements. The 2 dichlorophenol metabolites were positively associated with increased serum IgE levels in the larger study sample. Conclusion These findings indicate that in patients with atopy and a history of wheezing, asthma morbidity is associated with high urinary dichlorophenol levels. Increased urine dichlorophenol levels are associated with higher total serum IgE.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalAnnals of Allergy, Asthma and Immunology
Volume112
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Asthma
Urine
Morbidity
Respiratory Sounds
Odds Ratio
Immunoglobulin E
Serum
Nutrition Surveys
Phenols
Prescriptions
Exercise
Physicians
2,5-dichlorophenol

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

@article{1e92597d69c84fbca05afbab74d6f240,
title = "Relationship between urine dichlorophenol levels and asthma morbidity",
abstract = "Background Chlorinated phenols are associated with atopic conditions, but it is not known whether they are associated with wheeze or asthma and whether atopy is involved in these associations. Objectives To test the association between urine levels of 2 dichlorophenols (2,4- and 2,5-dichlorophenols) and asthma morbidity in atopic and nonatopic wheezers and between total serum immunoglobulin E (IgE) levels. Methods Data from a sample of 2,125 participants at least 6 years old from the US National Health and Nutrition Examination Survey 2005 to 2006 were analyzed. Asthma morbidity data were available for those participants who reported wheezing in the past year ({"}wheezers{"}; n = 250). This subsample was categorized as atopic or nonatopic. Results Atopic wheezers with higher 2,5-dichlorophenol levels were more frequently diagnosed with asthma by a physician (odds ratio [OR] 4.7 for highest vs lowest tertile, P <.001), required more prescriptions for asthma medications (OR 2.2, P =.046), and reported more exercise-induced wheezing (OR 5.8, P =.045) than atopic wheezers with low dichlorophenol levels. Atopic wheezers with higher 2,5- or 2,4-dichloropheonol levels also were more likely to miss work or school because of wheezing (OR 10.0, P <.001; OR 11.4, P <.01, respectively). In contrast, in nonatopic wheezers, there were no significant associations between dichlorophenol levels and asthma morbidity measurements. The 2 dichlorophenol metabolites were positively associated with increased serum IgE levels in the larger study sample. Conclusion These findings indicate that in patients with atopy and a history of wheezing, asthma morbidity is associated with high urinary dichlorophenol levels. Increased urine dichlorophenol levels are associated with higher total serum IgE.",
author = "Elina Jerschow and Purvi Parikh and McGinn, {Aileen P.} and {De Vos}, Gabriele and Jariwala, {Sunit P.} and Golda Hudes and Rosenstreich, {David L.}",
year = "2014",
doi = "10.1016/j.anai.2014.03.011",
language = "English (US)",
volume = "112",
pages = "511--518",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "6",

}

TY - JOUR

T1 - Relationship between urine dichlorophenol levels and asthma morbidity

AU - Jerschow, Elina

AU - Parikh, Purvi

AU - McGinn, Aileen P.

AU - De Vos, Gabriele

AU - Jariwala, Sunit P.

AU - Hudes, Golda

AU - Rosenstreich, David L.

PY - 2014

Y1 - 2014

N2 - Background Chlorinated phenols are associated with atopic conditions, but it is not known whether they are associated with wheeze or asthma and whether atopy is involved in these associations. Objectives To test the association between urine levels of 2 dichlorophenols (2,4- and 2,5-dichlorophenols) and asthma morbidity in atopic and nonatopic wheezers and between total serum immunoglobulin E (IgE) levels. Methods Data from a sample of 2,125 participants at least 6 years old from the US National Health and Nutrition Examination Survey 2005 to 2006 were analyzed. Asthma morbidity data were available for those participants who reported wheezing in the past year ("wheezers"; n = 250). This subsample was categorized as atopic or nonatopic. Results Atopic wheezers with higher 2,5-dichlorophenol levels were more frequently diagnosed with asthma by a physician (odds ratio [OR] 4.7 for highest vs lowest tertile, P <.001), required more prescriptions for asthma medications (OR 2.2, P =.046), and reported more exercise-induced wheezing (OR 5.8, P =.045) than atopic wheezers with low dichlorophenol levels. Atopic wheezers with higher 2,5- or 2,4-dichloropheonol levels also were more likely to miss work or school because of wheezing (OR 10.0, P <.001; OR 11.4, P <.01, respectively). In contrast, in nonatopic wheezers, there were no significant associations between dichlorophenol levels and asthma morbidity measurements. The 2 dichlorophenol metabolites were positively associated with increased serum IgE levels in the larger study sample. Conclusion These findings indicate that in patients with atopy and a history of wheezing, asthma morbidity is associated with high urinary dichlorophenol levels. Increased urine dichlorophenol levels are associated with higher total serum IgE.

AB - Background Chlorinated phenols are associated with atopic conditions, but it is not known whether they are associated with wheeze or asthma and whether atopy is involved in these associations. Objectives To test the association between urine levels of 2 dichlorophenols (2,4- and 2,5-dichlorophenols) and asthma morbidity in atopic and nonatopic wheezers and between total serum immunoglobulin E (IgE) levels. Methods Data from a sample of 2,125 participants at least 6 years old from the US National Health and Nutrition Examination Survey 2005 to 2006 were analyzed. Asthma morbidity data were available for those participants who reported wheezing in the past year ("wheezers"; n = 250). This subsample was categorized as atopic or nonatopic. Results Atopic wheezers with higher 2,5-dichlorophenol levels were more frequently diagnosed with asthma by a physician (odds ratio [OR] 4.7 for highest vs lowest tertile, P <.001), required more prescriptions for asthma medications (OR 2.2, P =.046), and reported more exercise-induced wheezing (OR 5.8, P =.045) than atopic wheezers with low dichlorophenol levels. Atopic wheezers with higher 2,5- or 2,4-dichloropheonol levels also were more likely to miss work or school because of wheezing (OR 10.0, P <.001; OR 11.4, P <.01, respectively). In contrast, in nonatopic wheezers, there were no significant associations between dichlorophenol levels and asthma morbidity measurements. The 2 dichlorophenol metabolites were positively associated with increased serum IgE levels in the larger study sample. Conclusion These findings indicate that in patients with atopy and a history of wheezing, asthma morbidity is associated with high urinary dichlorophenol levels. Increased urine dichlorophenol levels are associated with higher total serum IgE.

UR - http://www.scopus.com/inward/record.url?scp=84901441934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901441934&partnerID=8YFLogxK

U2 - 10.1016/j.anai.2014.03.011

DO - 10.1016/j.anai.2014.03.011

M3 - Article

C2 - 24726197

AN - SCOPUS:84901441934

VL - 112

SP - 511

EP - 518

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 6

ER -