Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-α gene expression and cytotoxicity

Catherine A. Burkhart, Susan Band Horwitz, Charles S. Swindell, Susan Band Horwitz

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Taxol is an antitumor drug with cytotoxic properties that correlate with its microtubule-stabilizing activities. It has been reported that taxol parallels lipopolysaccharide in its effects on the induction of tumor necrosis factor-α (TNF-α) gene expression in macrophages (C. Bogdan and A. Ding, J. Leukocyte Biol., 52: 119-121, 1992; C. L. Manthey, M. E. Brandes, P. Y. Perera, and S. Vogel, J. Immunol., 149: 2459-2465, 1992; J. M. Carboni, C. Singh, and M. A. Tepper, Natl. Cancer Inst. Monogr., 15: 95-101, 1993). Structure-activity studies using taxol and related taxanes have been done to determine the relationship between the effects of taxol on TNF-α gene expression and its cytotoxic and microtubule-stabilizing activities. Using Northern blot analysis, it was found that changes in the structure of taxol that did not alter cytotoxicity did prevent the induction of TNF-α gene expression. The data presented in this paper demonstrate that the effects of taxol on TNF-α gene expression are distinct from its known cytotoxic properties.

Original languageEnglish (US)
Pages (from-to)5779-5782
Number of pages4
JournalCancer Research
Volume54
Issue number22
StatePublished - Nov 15 1994

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Taxoids
Paclitaxel
Tumor Necrosis Factor-alpha
Gene Expression
Microtubules
Northern Blotting
Antineoplastic Agents
Lipopolysaccharides
Leukocytes
Macrophages
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-α gene expression and cytotoxicity. / Burkhart, Catherine A.; Band Horwitz, Susan; Swindell, Charles S.; Horwitz, Susan Band.

In: Cancer Research, Vol. 54, No. 22, 15.11.1994, p. 5779-5782.

Research output: Contribution to journalArticle

Burkhart, Catherine A. ; Band Horwitz, Susan ; Swindell, Charles S. ; Horwitz, Susan Band. / Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-α gene expression and cytotoxicity. In: Cancer Research. 1994 ; Vol. 54, No. 22. pp. 5779-5782.
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