Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation

M. S. Firstenberg, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, M. J. Garcia, J. D. Thomas

Research output: Contribution to journalConference article


Efforts to improve mitral regurgitation (MR) are often performed in conjunction with coronary revascularization. However, the independent effects of reduced MR area (MRa) are difficult to quantify. Using a previously developed cardiovascular model, ventricular contractility (elastance 1-8 mmHg/ml) and relaxation (tau: 40-150 msec) were independently adjusted for 4 grades of MR orifice areas (0.0 to 0.8 cm2). Improvements in forward stroke volume (fSV) were determined for the permutations of reduced MRa. For all conditions, LV end-diastolic pressure and volumes ranged from 7.3-24.2 mmHg and 64.8-174.3 ml, respectively. Overall, fSV ranged from 36.0-89.4 (mean: 64.2±12.8) ml, improved between 6.4 and 35.3% (mean: 15.6±8.1%), and was best predicted by (r=0.97, p<0.01): %Δ(fVS) = 34 [MRainital] - 46 [MRafinal] - 0.5 [elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalComputers in Cardiology
StatePublished - Dec 1 2001
Externally publishedYes
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001


ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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