Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation

M. S. Firstenberg, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, Mario J. Garcia, J. D. Thomas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Efforts to improve mitral regurgitation (MR) are often performed in conjunction with coronary revascularization. However, the independent effects of reduced MR area (MRa) are difficult to quantify. Using a previously developed cardiovascular model, ventricular contractility (elastance 1-8 mmHg/ml) and relaxation (tau: 40-150 msec) were independently adjusted for 4 grades of MR orifice areas (0.0 to 0.8 cm2). Improvements in forward stroke volume (fSV) were determined for the permutations of reduced MRa. For all conditions, LV end-diastolic pressure and volumes ranged from 7.3-24.2 mmHg and 64.8-174.3 ml, respectively. Overall, fSV ranged from 36.0-89.4 (mean: 64.2±12.8) ml, improved between 6.4 and 35.3% (mean: 15.6±8.1%), and was best predicted by (r=0.97, p<0.01): %Δ(fVS) = 34 [MRainital] - 46 [MRafinal] - 0.5 [elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages177-180
Number of pages4
StatePublished - 2001
Externally publishedYes
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001

Other

OtherComputer in Cardiology 2001
CountryNetherlands
CityRotterdam
Period9/23/019/26/01

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Mitral Valve Insufficiency
Orifices
Stroke Volume
Cardiovascular Models
Blood Pressure

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Firstenberg, M. S., Greenberg, N. L., Smedira, N. G., McCarthy, P. M., Garcia, M. J., & Thomas, J. D. (2001). Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation. In Computers in Cardiology (pp. 177-180)

Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation. / Firstenberg, M. S.; Greenberg, N. L.; Smedira, N. G.; McCarthy, P. M.; Garcia, Mario J.; Thomas, J. D.

Computers in Cardiology. 2001. p. 177-180.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Firstenberg, MS, Greenberg, NL, Smedira, NG, McCarthy, PM, Garcia, MJ & Thomas, JD 2001, Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation. in Computers in Cardiology. pp. 177-180, Computer in Cardiology 2001, Rotterdam, Netherlands, 9/23/01.
Firstenberg MS, Greenberg NL, Smedira NG, McCarthy PM, Garcia MJ, Thomas JD. Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation. In Computers in Cardiology. 2001. p. 177-180
Firstenberg, M. S. ; Greenberg, N. L. ; Smedira, N. G. ; McCarthy, P. M. ; Garcia, Mario J. ; Thomas, J. D. / Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation. Computers in Cardiology. 2001. pp. 177-180
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