Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women

Carole Fakhry, Gypsyamber D'souza, Elizabeth Sugar, Kathleen Weber, Eleni Goshu, Howard Minkoff, Rodney L. Wright, Eric Seaberg, Maura Gillison

Research output: Contribution to journalArticle

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Abstract

Human papillomavirus (HPV) is an etiologic agent for both oropharyngeal and cervical cancers, yet little is known about the interrelationship between oral and cervical HPV infections. Therefore, we compared the prevalences and type distributions of oral and cervical HPV infections and evaluated infection concordance in a cross-sectional study within the Women's Interagency HIV Study cohort. Oral rinse and cervical-vaginal lavage samples were concurrently collected from a convenience sample of 172 human immunodeficiency virus (HIV)-positive and 86 HIV-negative women. HPV genomic DNA was detected by PGMY09/11 L1 consensus primer PCR and type specified by reverse line blot hybridization for 37 HPV types and β-globin. Only 26 of the 35 HPV types found to infect the cervix were also found within the oral cavity, and the type distribution for oral HPV infections appeared distinct from that for cervical infections (P < 0.001). Oral HPV infections were less common than cervical infections for both HIV-positive (25.2% versus 76.9%, P < 0.001) and HIV-negative (9.0% versus 44.9%, P < 0.001) women. Oral HPV infections were more common among women with a cervical HPV infection than those without a cervical HPV infection (25.5% versus 7.9%, P = 0.002). The majority of women (207; 93.7%) did not have simultaneous oral and cervical infections by the same HPV type; however, the number of women who did (14; 6.3%) was significantly greater than would be expected by chance (P = 0.0002). Therefore, the oral and cervical reservoirs for HPV infection are likely not entirely independent of one another.

Original languageEnglish (US)
Pages (from-to)4479-4485
Number of pages7
JournalJournal of Clinical Microbiology
Volume44
Issue number12
DOIs
StatePublished - Dec 2006

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Papillomavirus Infections
HIV
Infection
Vaginal Douching
Oropharyngeal Neoplasms
Globins
Cervix Uteri
Uterine Cervical Neoplasms
Mouth
Cohort Studies

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women. / Fakhry, Carole; D'souza, Gypsyamber; Sugar, Elizabeth; Weber, Kathleen; Goshu, Eleni; Minkoff, Howard; Wright, Rodney L.; Seaberg, Eric; Gillison, Maura.

In: Journal of Clinical Microbiology, Vol. 44, No. 12, 12.2006, p. 4479-4485.

Research output: Contribution to journalArticle

Fakhry, Carole ; D'souza, Gypsyamber ; Sugar, Elizabeth ; Weber, Kathleen ; Goshu, Eleni ; Minkoff, Howard ; Wright, Rodney L. ; Seaberg, Eric ; Gillison, Maura. / Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women. In: Journal of Clinical Microbiology. 2006 ; Vol. 44, No. 12. pp. 4479-4485.
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