Relationship between Early Antibiotic Exposure and Short-Term Growth Velocity in Premature Neonates

Research output: Contribution to journalArticle

Abstract

Objective To characterize the relationship between the duration of antibiotic administration during the first week of life and subsequent growth velocity during hospitalization. Study Design This was a retrospective study comparing the inhospital growth of infants born between 30 and 32 6/7 weeks' gestational age (GA) admitted to the Montefiore Weiler and Wakefield neonatal intensive care units between January 2009 and December 2015. Antibiotic duration during the first week of life was classified as no antibiotics, <5 days of antibiotics, or ≥5 days of antibiotics. Differences between discharge and birth weight Z-scores were compared between the three groups using analysis of variance. Results Of the infants, 87% received antibiotics during the first week of life, with 16% of infants completing ≥5 days. Compared with infants receiving ≤ 5 days of antibiotics, infants treated with ≥5 days had a lower GA, lower Apgar scores, more invasive respiratory support, longer duration of total parenteral nutrition, delayed initiation of enteral feeding, and a higher weight Z-score on admission and discharge (p < 0.05). However, there was no distinction in growth between the three groups assessed by the difference between admission and discharge weight Z-scores (p = 0.64), growth velocity (gram/kilogram/day) (p = 0.104), or an exponential growth velocity outcome (p = 0.423). Conclusion Early antibiotic exposure was not associated with increased growth velocity between birth and discharge. Our study was limited by its retrospective nature and lack of follow-up data postdischarge.

Original languageEnglish (US)
Pages (from-to)1014-1022
Number of pages9
JournalAmerican Journal of Perinatology
Volume36
Issue number10
DOIs
StatePublished - Jan 1 2019

Fingerprint

Newborn Infant
Anti-Bacterial Agents
Growth
Gestational Age
Weights and Measures
Apgar Score
Total Parenteral Nutrition
Neonatal Intensive Care Units
Enteral Nutrition
Birth Weight
Analysis of Variance
Hospitalization
Retrospective Studies
Parturition

Keywords

  • antibiotics
  • growth
  • metabolic syndrome
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

@article{7629b4968abe451fb8ae33fd68b24775,
title = "Relationship between Early Antibiotic Exposure and Short-Term Growth Velocity in Premature Neonates",
abstract = "Objective To characterize the relationship between the duration of antibiotic administration during the first week of life and subsequent growth velocity during hospitalization. Study Design This was a retrospective study comparing the inhospital growth of infants born between 30 and 32 6/7 weeks' gestational age (GA) admitted to the Montefiore Weiler and Wakefield neonatal intensive care units between January 2009 and December 2015. Antibiotic duration during the first week of life was classified as no antibiotics, <5 days of antibiotics, or ≥5 days of antibiotics. Differences between discharge and birth weight Z-scores were compared between the three groups using analysis of variance. Results Of the infants, 87{\%} received antibiotics during the first week of life, with 16{\%} of infants completing ≥5 days. Compared with infants receiving ≤ 5 days of antibiotics, infants treated with ≥5 days had a lower GA, lower Apgar scores, more invasive respiratory support, longer duration of total parenteral nutrition, delayed initiation of enteral feeding, and a higher weight Z-score on admission and discharge (p < 0.05). However, there was no distinction in growth between the three groups assessed by the difference between admission and discharge weight Z-scores (p = 0.64), growth velocity (gram/kilogram/day) (p = 0.104), or an exponential growth velocity outcome (p = 0.423). Conclusion Early antibiotic exposure was not associated with increased growth velocity between birth and discharge. Our study was limited by its retrospective nature and lack of follow-up data postdischarge.",
keywords = "antibiotics, growth, metabolic syndrome, prematurity",
author = "Reid, {Brittany M.} and Ruth Eisenberg and Katie Forman and Latuga, {Mariam Susan}",
year = "2019",
month = "1",
day = "1",
doi = "10.1055/s-0038-1675833",
language = "English (US)",
volume = "36",
pages = "1014--1022",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "10",

}

TY - JOUR

T1 - Relationship between Early Antibiotic Exposure and Short-Term Growth Velocity in Premature Neonates

AU - Reid, Brittany M.

AU - Eisenberg, Ruth

AU - Forman, Katie

AU - Latuga, Mariam Susan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective To characterize the relationship between the duration of antibiotic administration during the first week of life and subsequent growth velocity during hospitalization. Study Design This was a retrospective study comparing the inhospital growth of infants born between 30 and 32 6/7 weeks' gestational age (GA) admitted to the Montefiore Weiler and Wakefield neonatal intensive care units between January 2009 and December 2015. Antibiotic duration during the first week of life was classified as no antibiotics, <5 days of antibiotics, or ≥5 days of antibiotics. Differences between discharge and birth weight Z-scores were compared between the three groups using analysis of variance. Results Of the infants, 87% received antibiotics during the first week of life, with 16% of infants completing ≥5 days. Compared with infants receiving ≤ 5 days of antibiotics, infants treated with ≥5 days had a lower GA, lower Apgar scores, more invasive respiratory support, longer duration of total parenteral nutrition, delayed initiation of enteral feeding, and a higher weight Z-score on admission and discharge (p < 0.05). However, there was no distinction in growth between the three groups assessed by the difference between admission and discharge weight Z-scores (p = 0.64), growth velocity (gram/kilogram/day) (p = 0.104), or an exponential growth velocity outcome (p = 0.423). Conclusion Early antibiotic exposure was not associated with increased growth velocity between birth and discharge. Our study was limited by its retrospective nature and lack of follow-up data postdischarge.

AB - Objective To characterize the relationship between the duration of antibiotic administration during the first week of life and subsequent growth velocity during hospitalization. Study Design This was a retrospective study comparing the inhospital growth of infants born between 30 and 32 6/7 weeks' gestational age (GA) admitted to the Montefiore Weiler and Wakefield neonatal intensive care units between January 2009 and December 2015. Antibiotic duration during the first week of life was classified as no antibiotics, <5 days of antibiotics, or ≥5 days of antibiotics. Differences between discharge and birth weight Z-scores were compared between the three groups using analysis of variance. Results Of the infants, 87% received antibiotics during the first week of life, with 16% of infants completing ≥5 days. Compared with infants receiving ≤ 5 days of antibiotics, infants treated with ≥5 days had a lower GA, lower Apgar scores, more invasive respiratory support, longer duration of total parenteral nutrition, delayed initiation of enteral feeding, and a higher weight Z-score on admission and discharge (p < 0.05). However, there was no distinction in growth between the three groups assessed by the difference between admission and discharge weight Z-scores (p = 0.64), growth velocity (gram/kilogram/day) (p = 0.104), or an exponential growth velocity outcome (p = 0.423). Conclusion Early antibiotic exposure was not associated with increased growth velocity between birth and discharge. Our study was limited by its retrospective nature and lack of follow-up data postdischarge.

KW - antibiotics

KW - growth

KW - metabolic syndrome

KW - prematurity

UR - http://www.scopus.com/inward/record.url?scp=85070836723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070836723&partnerID=8YFLogxK

U2 - 10.1055/s-0038-1675833

DO - 10.1055/s-0038-1675833

M3 - Article

C2 - 30500965

AN - SCOPUS:85070836723

VL - 36

SP - 1014

EP - 1022

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 10

ER -