@article{fde609ebca5f4f57a061196f5a58c11f,
title = "Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus",
abstract = "Human leukocyte antigen (HLA) genotype has been associated with the probability of spontaneous clearance of hepatitis C virus (HCV). However, no prior studies have examined whether this relationship may be further characterized by grouping HLA alleles according to their supertypes, defined by their binding capacities. There is debate regarding the most appropriate method to define supertypes. Therefore, previously reported HLA supertypes (46 class I and 25 class II) were assessed for their relation with HCV clearance in a population of 758 HCV-seropositive women. Two HLA class II supertypes were significant in multivariable models that included: (i) supertypes with significant or borderline associations with HCV clearance after adjustment for multiple tests, and (ii) individual HLA alleles not part of these supertypes, but associated with HCV clearance in our prior study in this population. Specifically, supertype DRB3 (prevalence ratio (PR)=0.4; P=0.004) was associated with HCV persistence, whereas DR8 (PR=1.8; P=0.01) was associated with HCV clearance. Two individual alleles (B*57:01 and C*01:02) associated with HCV clearance in our prior study became nonsignificant in analysis that included supertypes, whereas B*57:03 (PR=1.9; P=0.008) and DRB1*07:01 (PR=1.7; P=0.005) retained their significance. These data provide epidemiologic support for the significance of HLA supertypes in relation to HCV clearance.",
keywords = "Hepatitis C virus, Human leukocyte antigen, Supertype",
author = "Kuniholm, {M. H.} and K. Anastos and A. Kovacs and X. Gao and D. Marti and A. Sette and Greenblatt, {R. M.} and M. Peters and Cohen, {M. H.} and H. Minkoff and Gange, {S. J.} and Thio, {C. L.} and Young, {M. A.} and X. Xue and M. Carrington and Strickler, {H. D.}",
note = "Funding Information: Funding for the current project was provided in part by R01AI057006 (HDS) in addition to the National Center for Research Resources CTSA grants UL1RR025750, KL2RR025749 and TL1RR025748, and from the National Institute of Allergy and Infectious Diseases grant R01A1052065 (AAK). Clinical data and specimens used in this study were collected by the Women{\textquoteright}s Interagency HIV Study (WIHS) Collaborative Study Group with centers (principal investigators) at New York City/Bronx Consortium (KA); Brooklyn, NY (HM); Washington DC, Metropolitan Consortium (MY); The Connie Wofsy Study Consortium of Northern California (RG); Los Angeles County/Southern California Consortium (AL); Chicago Consortium (MC); Data Coordinating Center (SG). The WIHS is funded by the National Institute of Allergy and Infectious Diseases (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993 and UO1-AI-42590) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (UO1-HD-32632). The study is co-funded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (UCSF-CTSI grant number UL1 RR024131). This project has also been funded in part with federal funds from the Frederick National Laboratory for Cancer Research, the National Institutes of Health under Contract No. HHSN261200800001E. This research was also supported in part by the Intramural Research Program of the NIH, Frederick National Laboratory, Center for Cancer Research and by the Einstein–Montefiore Center for AIDS Research (5P30AI051519-08).",
year = "2013",
month = jul,
doi = "10.1038/gene.2013.25",
language = "English (US)",
volume = "14",
pages = "330--335",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "5",
}
