Relapsed and refractory pediatric acute myeloid leukemia: Current and emerging treatments

Jennifer Davila, Emily Slotkin, Thomas Renaud

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Survival rates for children with acute myeloid leukemia (AML) exceed 60 % when modern, intensified chemotherapeutic regimens and enhanced supportive care measures are employed. Despite well-recognized improvements in outcomes, primary refractory or relapsed pediatric AML yields significant morbidity and mortality, and improved understanding of this obstinate population along with refined treatment protocols are urgently needed. Although a significant number of patients with refractory or relapsed disease will achieve remission, long-term survival rates remain poor, and efforts to identify therapies which will improve OS are under continuous investigation. The current fundamental goal of such investigation is the achievement of as complete a remission as possible without dose-limiting toxicities, and the progression to hematopoietic stem cell transplantation thereafter. In this review the scope of the problem of relapsed and refractory AML as well as current and emerging chemotherapy options will be discussed.

Original languageEnglish (US)
Pages (from-to)151-168
Number of pages18
JournalPediatric Drugs
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

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