Reinforcement of high-risk anastomoses using laser-activated protein solders: a clinical study

Steven K.M.D. Libutti, M. Bessler, J. Chabot, Lawrence S.M.D. Bass, Mehmet C.M.D. Oz, et.al.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Anastomotic leakage or breakdown can result in catastrophic complications and significantly increased post-operative morbidity and mortality. Certain anastomoses are subject to a higher incidence of disruption and are therefore termed high risk. In an attempt to decrease the risk of anastomotic leaks, we reinforced sutured anastomoses with a laser activated protein solder in patients undergoing esophagojejunostomies (n = 2), lung transplantation (n = 2), and pancreaticojejunostomies (Whipple procedure, n = 5). The protein solder was composed of 1.0 ml of a 25% human albumin solution, 1.0 ml of sodium hyaluronate, and 0.1 ml of Cardiogreen dye. This composition was applied to the sutured anastomosis and activated with an 860 nm pulsed diode laser. Drains were placed when appropriate and patients were followed for up to 10 months post-operatively and assessed for clinical signs of anastomotic leaks. Results to data demonstrated that there were no immediate complications as a result of the procedure. Operative time was not significantly lengthened. There were no cases of clinically significant leakage from any of the reinforced anastomoses. Laser activated protein solders may help to reduce the incidence of leakage in high risk anastomoses. Large numbers of patients and longer follow-up is needed however, to draw significant conclusions.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages164-167
Number of pages4
ISBN (Print)0819411035
Publication statusPublished - Jan 1 1993
EventLasers in Otolaryngology, Dermatology, and Tissue Welding - Los Angeles, CA, USA
Duration: Jan 16 1993Jan 18 1993

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1876
ISSN (Print)0277-786X

Other

OtherLasers in Otolaryngology, Dermatology, and Tissue Welding
CityLos Angeles, CA, USA
Period1/16/931/18/93

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Libutti, S. K. M. D., Bessler, M., Chabot, J., Bass, L. S. M. D., Oz, M. C. M. D., & et.al. (1993). Reinforcement of high-risk anastomoses using laser-activated protein solders: a clinical study. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 164-167). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1876). Publ by Society of Photo-Optical Instrumentation Engineers.