Reinforcement of high-risk anastomoses using laser-activated protein solders

a clinical study

Steven K M D Libutti, M. Bessler, J. Chabot, Lawrence S M D Bass, Mehmet C M D Oz, [No Value] et.al.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Anastomotic leakage or breakdown can result in catastrophic complications and significantly increased post-operative morbidity and mortality. Certain anastomoses are subject to a higher incidence of disruption and are therefore termed high risk. In an attempt to decrease the risk of anastomotic leaks, we reinforced sutured anastomoses with a laser activated protein solder in patients undergoing esophagojejunostomies (n = 2), lung transplantation (n = 2), and pancreaticojejunostomies (Whipple procedure, n = 5). The protein solder was composed of 1.0 ml of a 25% human albumin solution, 1.0 ml of sodium hyaluronate, and 0.1 ml of Cardiogreen dye. This composition was applied to the sutured anastomosis and activated with an 860 nm pulsed diode laser. Drains were placed when appropriate and patients were followed for up to 10 months post-operatively and assessed for clinical signs of anastomotic leaks. Results to data demonstrated that there were no immediate complications as a result of the procedure. Operative time was not significantly lengthened. There were no cases of clinically significant leakage from any of the reinforced anastomoses. Laser activated protein solders may help to reduce the incidence of leakage in high risk anastomoses. Large numbers of patients and longer follow-up is needed however, to draw significant conclusions.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages164-167
Number of pages4
Volume1876
ISBN (Print)0819411035
StatePublished - 1993
Externally publishedYes
EventLasers in Otolaryngology, Dermatology, and Tissue Welding - Los Angeles, CA, USA
Duration: Jan 16 1993Jan 18 1993

Other

OtherLasers in Otolaryngology, Dermatology, and Tissue Welding
CityLos Angeles, CA, USA
Period1/16/931/18/93

Fingerprint

solders
reinforcement
Soldering alloys
Reinforcement
leakage
proteins
Proteins
Lasers
incidence
lasers
transplantation
mortality
albumins
lungs
Semiconductor lasers
Dyes
breakdown
dyes
semiconductor lasers
Sodium

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Libutti, S. K. M. D., Bessler, M., Chabot, J., Bass, L. S. M. D., Oz, M. C. M. D., & et.al., N. V. (1993). Reinforcement of high-risk anastomoses using laser-activated protein solders: a clinical study. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1876, pp. 164-167). Publ by Society of Photo-Optical Instrumentation Engineers.

Reinforcement of high-risk anastomoses using laser-activated protein solders : a clinical study. / Libutti, Steven K M D; Bessler, M.; Chabot, J.; Bass, Lawrence S M D; Oz, Mehmet C M D; et.al., [No Value].

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1876 Publ by Society of Photo-Optical Instrumentation Engineers, 1993. p. 164-167.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Libutti, SKMD, Bessler, M, Chabot, J, Bass, LSMD, Oz, MCMD & et.al., NV 1993, Reinforcement of high-risk anastomoses using laser-activated protein solders: a clinical study. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 1876, Publ by Society of Photo-Optical Instrumentation Engineers, pp. 164-167, Lasers in Otolaryngology, Dermatology, and Tissue Welding, Los Angeles, CA, USA, 1/16/93.
Libutti SKMD, Bessler M, Chabot J, Bass LSMD, Oz MCMD, et.al. NV. Reinforcement of high-risk anastomoses using laser-activated protein solders: a clinical study. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1876. Publ by Society of Photo-Optical Instrumentation Engineers. 1993. p. 164-167
Libutti, Steven K M D ; Bessler, M. ; Chabot, J. ; Bass, Lawrence S M D ; Oz, Mehmet C M D ; et.al., [No Value]. / Reinforcement of high-risk anastomoses using laser-activated protein solders : a clinical study. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1876 Publ by Society of Photo-Optical Instrumentation Engineers, 1993. pp. 164-167
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