Regulation of WASp by phosphorylation activation or other functions?

Athanassios Dovas, Dianne Cox

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Wiskott-Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor that regulates actin polymerisation via the Arp2/3 complex. Its mutation in human syndromes has led to extensive studies on the regulation and activities of this molecule. Several mechanisms for the regulation of WASp activity have been proposed, however, the role of tyrosine phosphorylation remains controversial, particularly due to inconsistencies between results obtained through biochemical and cell biological approaches. In this mini-review, we are addressing the major aspects of WASp regulation with an emphasis on the role of tyrosine phosphorylation on WASp activities.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalCommunicative and Integrative Biology
Volume3
Issue number2
DOIs
StatePublished - Mar 1 2010

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Keywords

  • Actin polymerisation
  • Activation
  • Localisation
  • Phosphorylation
  • Protein degradation
  • Wiskott-aldrich syndrome protein

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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