Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis

Haein Park, Dan Ishihara, Dianne Cox

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Macrophages display a large variety of surface receptors that are critical for their normal cellular functions in host defense, including finding sites of infection (chemotaxis) and removing foreign particles (phagocytosis). However, inappropriate regulation of these processes can lead to human diseases. Many of these receptors utilize tyrosine phosphorylation cascades to initiate and terminate signals leading to cell migration and clearance of infection. Actin remodeling dominates these processes and many regulators have been identified. This review focuses on how tyrosine kinases and phosphatases regulate actin dynamics leading to macrophage chemotaxis and phagocytosis.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalArchives of Biochemistry and Biophysics
Volume510
Issue number2
DOIs
StatePublished - Jun 15 2011

Keywords

  • Chemotaxis
  • Kinase
  • Macrophage
  • Phagocytosis
  • Phosphatase
  • Signal transduction

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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