Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

Jörn M. Schattenberg, Mark J. Czaja

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in large part through overactivation of JNK that alters cell death pathways. Targeting the JNK pathway or its downstream effectors may be a useful therapeutic approach to the oxidative stress generated by CYP2E1 in alcoholic liver disease.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalRedox Biology
Volume3
DOIs
StatePublished - 2014

Fingerprint

Cytochrome P-450 CYP2E1
Oxidative stress
Reactive Oxygen Species
Oxidative Stress
Phosphotransferases
Liver
Hepatocytes
Alcohols
Alcoholic Liver Diseases
Signal transduction
JNK Mitogen-Activated Protein Kinases
Wounds and Injuries
Cell death
Fatty Liver
Mitogen-Activated Protein Kinases
Macromolecules
Oxidants
Signal Transduction
Cell Death
Cells

Keywords

  • Alcoholic liver disease
  • C-Jun N-terminal kinase
  • Cytochrome P450 2E1
  • Mitogen-activated protein kinases
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. / Schattenberg, Jörn M.; Czaja, Mark J.

In: Redox Biology, Vol. 3, 2014, p. 7-15.

Research output: Contribution to journalArticle

Schattenberg, Jörn M. ; Czaja, Mark J. / Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. In: Redox Biology. 2014 ; Vol. 3. pp. 7-15.
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