TY - JOUR
T1 - Regulation of the actin cytoskeleton in cancer cell migration and invasion
AU - Yamaguchi, Hideki
AU - Condeelis, John
N1 - Funding Information:
We apologize to those authors whose work we were unable to cite because of space and date of publication limitations. We are grateful to all lab members and collaborators for their support and helpful discussions. This work was supported by grants from the NIH (GM38511 and CA100324).
PY - 2007/5
Y1 - 2007/5
N2 - Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step processes initiated by the formation of membrane protrusions in response to migratory and chemotactic stimuli. The driving force for membrane protrusion is localized polymerization of submembrane actin filaments. Recently, several studies revealed that molecules that link migratory signals to the actin cytoskeleton are upregulated in invasive and metastatic cancer cells. In this review, we summarize recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIM-kinase, cofilin, and cortactin.
AB - Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step processes initiated by the formation of membrane protrusions in response to migratory and chemotactic stimuli. The driving force for membrane protrusion is localized polymerization of submembrane actin filaments. Recently, several studies revealed that molecules that link migratory signals to the actin cytoskeleton are upregulated in invasive and metastatic cancer cells. In this review, we summarize recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIM-kinase, cofilin, and cortactin.
KW - Cell motility
KW - Cofilin
KW - Cortactin
KW - Invadopodia
KW - Lamellipodia
KW - WASP family
UR - http://www.scopus.com/inward/record.url?scp=34247468876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247468876&partnerID=8YFLogxK
U2 - 10.1016/j.bbamcr.2006.07.001
DO - 10.1016/j.bbamcr.2006.07.001
M3 - Review article
C2 - 16926057
AN - SCOPUS:34247468876
SN - 0167-4889
VL - 1773
SP - 642
EP - 652
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 5
ER -
