Regulation of Tcl transposable elements in Caenorhabditis elegans.

Scott W. Emmons, K. S. Ruan, A. Levitt, L. Yesner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

C. elegans strains contain variable numbers of a 1.6-kb transposable genetic element. Activity of this element, which is denoted Tcl, shows regulation at at least two levels. At one level, excision of Tcl elements occurs in somatic cells at a frequency several orders of magnitude higher than in germ cells. Evidence is presented suggesting that this results from regulation at the level of trans-acting functions that are required for excision or that repress excision. At the second level, germ line transposition of Tcl occurs at greater frequency in some strains than in others. The hypothesis is proposed that this is because Tcl is one component of a two-element system, the second element of which differs between strains. Evidence for a second putative transposable element family in C. elegans is presented. This family has properties that suggest a relationship to Tcl. This possibility is currently under investigation.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume50
StatePublished - 1985
Externally publishedYes

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DNA Transposable Elements
Caenorhabditis elegans
Germ Cells
transposons
germ cells
transposition (genetics)
somatic cells
Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Molecular Biology

Cite this

Regulation of Tcl transposable elements in Caenorhabditis elegans. / Emmons, Scott W.; Ruan, K. S.; Levitt, A.; Yesner, L.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 50, 1985, p. 313-320.

Research output: Contribution to journalArticle

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