Regulation of pol III transcription by nutrient and stress signaling pathways

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58 Citations (Scopus)

Abstract

Transcription by RNA polymerase III (pol III) is responsible for ~. 15% of total cellular transcription through the generation of small structured RNAs such as tRNA and 5S RNA. The coordinate synthesis of these molecules with ribosomal protein mRNAs and rRNA couples the production of ribosomes and their tRNA substrates and balances protein synthetic capacity with the growth requirements of the cell. Ribosome biogenesis in general and pol III transcription in particular is known to be regulated by nutrient availability, cell stress and cell cycle stage and is perturbed in pathological states. High throughput proteomic studies have catalogued modifications to pol III subunits, assembly, initiation and accessory factors but most of these modifications have yet to be linked to functional consequences. Here we review our current understanding of the major points of regulation in the pol III transcription apparatus, the targets of regulation and the signaling pathways known to regulate their function. This article is part of a Special Issue entitled: Transcription by Odd Pols.

Original languageEnglish (US)
Pages (from-to)361-375
Number of pages15
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number3-4
DOIs
StatePublished - Mar 2013

Fingerprint

Transcription
Transfer RNA
Ribosomes
Nutrients
RNA
RNA Polymerase III
Food
Peptide Initiation Factors
Ribosomal Proteins
Proteomics
Cell Cycle
Messenger RNA
Growth
Accessories
Proteins
Cells
Throughput
Availability
Molecules
Substrates

Keywords

  • Cyclin-like kinase
  • Glycogen synthase kinase
  • Kns1
  • Maf1
  • Protein kinase A
  • Protein kinase CK2
  • Rapamycin-sensitive TOR signaling

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

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abstract = "Transcription by RNA polymerase III (pol III) is responsible for ~. 15{\%} of total cellular transcription through the generation of small structured RNAs such as tRNA and 5S RNA. The coordinate synthesis of these molecules with ribosomal protein mRNAs and rRNA couples the production of ribosomes and their tRNA substrates and balances protein synthetic capacity with the growth requirements of the cell. Ribosome biogenesis in general and pol III transcription in particular is known to be regulated by nutrient availability, cell stress and cell cycle stage and is perturbed in pathological states. High throughput proteomic studies have catalogued modifications to pol III subunits, assembly, initiation and accessory factors but most of these modifications have yet to be linked to functional consequences. Here we review our current understanding of the major points of regulation in the pol III transcription apparatus, the targets of regulation and the signaling pathways known to regulate their function. This article is part of a Special Issue entitled: Transcription by Odd Pols.",
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AU - Willis, Ian M.

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KW - Rapamycin-sensitive TOR signaling

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