Regulation of Notch signaling by glycosylation

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Notch receptors are ∼300 kDa cell surface glycoproteins whose activation by Notch ligands regulates cell fate decisions in the metazoa. The extracellular domain of Notch receptors has many epidermal growth factor like repeats that are glycosylated with O-fucose and O-glucose glycans as well as N-glycans. Disruption of O-fucose glycan synthesis leads to severe Notch signaling defects in Drosophila and mammals. Removal or addition of O-fucose glycan consensus sites on Notch receptors also leads to Notch signaling defects. Ligand binding and ligand-induced Notch signaling assays have provided insights into how changes in the O-fucose glycans of Notch receptors alter Notch signaling.

Original languageEnglish (US)
Pages (from-to)530-535
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume17
Issue number5
DOIs
StatePublished - Oct 2007

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Notch Receptors
Glycosylation
Fucose
Polysaccharides
Ligands
Membrane Glycoproteins
Epidermal Growth Factor
Drosophila
Mammals
Glucose

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Regulation of Notch signaling by glycosylation. / Stanley, Pamela.

In: Current Opinion in Structural Biology, Vol. 17, No. 5, 10.2007, p. 530-535.

Research output: Contribution to journalArticle

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