Regulation of Notch signaling by glycosylation

Research output: Contribution to journalReview article

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Abstract

Notch receptors are ∼300 kDa cell surface glycoproteins whose activation by Notch ligands regulates cell fate decisions in the metazoa. The extracellular domain of Notch receptors has many epidermal growth factor like repeats that are glycosylated with O-fucose and O-glucose glycans as well as N-glycans. Disruption of O-fucose glycan synthesis leads to severe Notch signaling defects in Drosophila and mammals. Removal or addition of O-fucose glycan consensus sites on Notch receptors also leads to Notch signaling defects. Ligand binding and ligand-induced Notch signaling assays have provided insights into how changes in the O-fucose glycans of Notch receptors alter Notch signaling.

Original languageEnglish (US)
Pages (from-to)530-535
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2007

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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