Regulation of Nicotinate Phosphoribosyltransferase in Brevibacterium ammoniagenes ATCC 6872

Natalia Dulianinova, E. M. Podlepa, V. P. Radina, V. Zh Tsyrenov, V. Ya Bykhovskii

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nicotinate phosphoribosyltransferase from Brevibacterium ammoniagenes ATCC 6872 (500-fold purification) was inhibited by the reaction products (nicotinic acid mononucleotide, pyrophosphate and ADP). Deamido NAD and NAD also had inhibitory effects. Nicotinamide, nicotinamide mononucleotide adenine, adenosine, polyadenylic acid, adenosine 5′-tetraphosphate, ribose 5-phosphate, nucleoside monophosphates, flavin mononucleotide, flavin adenine dinucleotide, or NADP did not affect the enzyme activity. CTP, ITP, GTP, and UTP could substitute ATP in this reaction. However, the affinity of the enzyme for the above-listed nucleoside triphosphates was lower than the affinity for ATP.

Original languageEnglish (US)
Pages (from-to)22-23
Number of pages2
JournalPrikladnaya Biokhimiya i Mikrobiologiya
Volume33
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Brevibacterium
Nucleosides
Nicotinamide Mononucleotide
Adenosine Triphosphate
Inosine Triphosphate
Flavin Mononucleotide
Cytidine Triphosphate
Uridine Triphosphate
Poly A
Flavin-Adenine Dinucleotide
Niacinamide
Enzyme activity
Adenine
Enzymes
Guanosine Triphosphate
NADP
Reaction products
NAD
Adenosine
Adenosine Diphosphate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Regulation of Nicotinate Phosphoribosyltransferase in Brevibacterium ammoniagenes ATCC 6872. / Dulianinova, Natalia; Podlepa, E. M.; Radina, V. P.; Tsyrenov, V. Zh; Bykhovskii, V. Ya.

In: Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 33, No. 1, 1997, p. 22-23.

Research output: Contribution to journalArticle

Dulianinova, Natalia ; Podlepa, E. M. ; Radina, V. P. ; Tsyrenov, V. Zh ; Bykhovskii, V. Ya. / Regulation of Nicotinate Phosphoribosyltransferase in Brevibacterium ammoniagenes ATCC 6872. In: Prikladnaya Biokhimiya i Mikrobiologiya. 1997 ; Vol. 33, No. 1. pp. 22-23.
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