Regulation of Liver Metabolism by Autophagy

Julio Madrigal-Matute, Ana Maria Cuervo

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Intracellular components must be recycled for cells to maintain energy and ensure quality control of proteins and organelles. Autophagy is a highly conserved recycling process that involves degradation of cellular constituents in lysosomes. Although autophagy regulates a number of cell functions, it was first found to maintain energy balance in liver cells. As our understanding of autophagy has increased, we have found its connections to energy regulation in liver cells to be tight and complex. We review 3 mechanisms by which hepatic autophagy monitors and regulates cellular metabolism. Autophagy provides essential components (amino acids, lipids, and carbohydrates) required to meet the cell's energy needs, and it also regulates energy supply by controlling the number, quality, and dynamics of the mitochondria. Finally, autophagy also modulates levels of enzymes in metabolic pathways. In light of the multiple ways in which autophagy participates to control liver metabolism, it is no surprise that dysregulation of autophagy has been associated with metabolic diseases such as obesity, diabetes, or metabolic syndrome, as well as liver-specific disorders such as fatty liver, nonalcoholic steatohepatitis, and hepatocellular carcinoma. We discuss some of these connections and how hepatic autophagy might serve as a therapeutic target in common metabolic disorders.

Original languageEnglish (US)
Pages (from-to)328-339
Number of pages12
JournalGastroenterology
Volume150
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Autophagy
Liver
Essential Amino Acids
Metabolic Diseases
Recycling
Fatty Liver
Metabolic Networks and Pathways
Lysosomes
Quality Control
Organelles
Hepatocellular Carcinoma
Mitochondria
Obesity
Cell Count
Carbohydrates
Lipids
Enzymes

Keywords

  • Cancer
  • Chaperone-Mediated Autophagy
  • Lipophagy
  • Lysosome
  • Macroautophagy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Regulation of Liver Metabolism by Autophagy. / Madrigal-Matute, Julio; Cuervo, Ana Maria.

In: Gastroenterology, Vol. 150, No. 2, 01.02.2016, p. 328-339.

Research output: Contribution to journalArticle

Madrigal-Matute, Julio ; Cuervo, Ana Maria. / Regulation of Liver Metabolism by Autophagy. In: Gastroenterology. 2016 ; Vol. 150, No. 2. pp. 328-339.
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