Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels

Juan A. Orellana, Kurt A. Schalper, Vania Figueroa, Helmuth A. Sánchez, Juan C. Sáez

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

Abstract

The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins that constitute the molecular basis of two kinds of channels: gap junction channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and hemichannels (HCs) that provide a pathway for exchanges between the intra and extra-cellular milieu. Both kind of connexin-based channels support intercellular communication via intercellular propagation of calcium waves. Here, we review evidence supporting the role of Ca 2+ in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca 2+ signals.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages777-794
Number of pages18
Volume740
DOIs
StatePublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume740
ISSN (Print)00652598

Fingerprint

Connexins
Calcium Signaling
Calcium
Gap Junctions
Cytoplasm
Communication
Cell Communication
Synchronization
Membrane Proteins

Keywords

  • Calcium waves
  • Calmodulin
  • Connexons
  • Dye coupling
  • Gap junctions
  • Hemichannels

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Orellana, J. A., Schalper, K. A., Figueroa, V., Sánchez, H. A., & Sáez, J. C. (2012). Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. In Advances in Experimental Medicine and Biology (Vol. 740, pp. 777-794). (Advances in Experimental Medicine and Biology; Vol. 740). https://doi.org/10.1007/978-94-007-2888-2_34

Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. / Orellana, Juan A.; Schalper, Kurt A.; Figueroa, Vania; Sánchez, Helmuth A.; Sáez, Juan C.

Advances in Experimental Medicine and Biology. Vol. 740 2012. p. 777-794 (Advances in Experimental Medicine and Biology; Vol. 740).

Research output: Chapter in Book/Report/Conference proceedingChapter

Orellana, JA, Schalper, KA, Figueroa, V, Sánchez, HA & Sáez, JC 2012, Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. in Advances in Experimental Medicine and Biology. vol. 740, Advances in Experimental Medicine and Biology, vol. 740, pp. 777-794. https://doi.org/10.1007/978-94-007-2888-2_34
Orellana JA, Schalper KA, Figueroa V, Sánchez HA, Sáez JC. Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. In Advances in Experimental Medicine and Biology. Vol. 740. 2012. p. 777-794. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-007-2888-2_34
Orellana, Juan A. ; Schalper, Kurt A. ; Figueroa, Vania ; Sánchez, Helmuth A. ; Sáez, Juan C. / Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Advances in Experimental Medicine and Biology. Vol. 740 2012. pp. 777-794 (Advances in Experimental Medicine and Biology).
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