@inbook{5fc459017aee4a339a4793f979b060b2,
title = "Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels",
abstract = "The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins that constitute the molecular basis of two kinds of channels: gap junction channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and hemichannels (HCs) that provide a pathway for exchanges between the intra and extra-cellular milieu. Both kind of connexin-based channels support intercellular communication via intercellular propagation of calcium waves. Here, we review evidence supporting the role of Ca 2+ in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca 2+ signals.",
keywords = "Calcium waves, Calmodulin, Connexons, Dye coupling, Gap junctions, Hemichannels",
author = "Orellana, {Juan A.} and Schalper, {Kurt A.} and Vania Figueroa and S{\'a}nchez, {Helmuth A.} and S{\'a}ez, {Juan C.}",
note = "Funding Information: This work was partially supported by the CONICYT 79090028 (to JAO); FONDECYT 1111033 (to JCS); FONDEF DO7I1086 (to JCS); and ANILLO ACT-71 (to JCS) grants.",
year = "2012",
doi = "10.1007/978-94-007-2888-2_34",
language = "English (US)",
isbn = "9789400728875",
series = "Advances in Experimental Medicine and Biology",
pages = "777--794",
booktitle = "Calcium Signaling",
}