Regulation of IGF -1 signaling by microRNAs

Hwa Jin Jung, Yousin Suh

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological processes including development, homeostasis, and aging. Dysregulation of this pathway has been implicated in a myriad of diseases such as cancers, neurodegenerative diseases, and metabolic disorders, making the IGF-1 signaling pathway a prime target to develop therapeutic and intervention strategies. Recently, small non-coding RNA molecules in ~22 nucleotide length, microRNAs (miRNAs), have emerged as a new regulator of biological processes in virtually all organ systems and increasing studies are linking altered miRNA function to disease mechanisms. A miRNA binds to 3'UTRs of multiple target genes and coordinately downregulates their expression, thereby exerting a profound influence on gene regulatory networks. Here we review the components of the IGF-1 signaling pathway that are known targets of miRNA regulation, and highlight recent studies that suggest therapeutic potential of these miRNAs against various diseases.

Original languageEnglish (US)
Article number472
JournalFrontiers in Genetics
Volume5
Issue numberJAN
DOIs
StatePublished - 2015

Keywords

  • Aging
  • Aging-related disease
  • IGF-1 signaling
  • Micrornas
  • Therapeutic agents

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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