Regulation of hematopoiesis by growth factors

E. Richard Stanley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The history of the role of hematopoietic growth factors (HGFs) in the regulation of hematopoiesis is briefly reviewed, commencing with the studies that defined the hematopoietic stem cell and led to the development of in vitro assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the "permissive" versus "instructive" models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor-1 (CSF-1), is reviewed, including its function in development as revealed by studies of mouse mutants and its role in innate immunity, inflammatory disease and cancer.

Original languageEnglish (US)
Title of host publicationNATO Security through Science Series C: Environmental Security
Pages63-75
Number of pages13
DOIs
StatePublished - 2008

Publication series

NameNATO Security through Science Series C: Environmental Security
ISSN (Print)18714668

Fingerprint

synergism
immunity
cancer
regulation
history
mutant
in vitro assay

Keywords

  • Blood cells
  • CSF-1
  • Macrophages
  • Osteoclasts
  • Review

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Richard Stanley, E. (2008). Regulation of hematopoiesis by growth factors. In NATO Security through Science Series C: Environmental Security (pp. 63-75). (NATO Security through Science Series C: Environmental Security). https://doi.org/10.1007/978-1-4020-6469-2-5

Regulation of hematopoiesis by growth factors. / Richard Stanley, E.

NATO Security through Science Series C: Environmental Security. 2008. p. 63-75 (NATO Security through Science Series C: Environmental Security).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Richard Stanley, E 2008, Regulation of hematopoiesis by growth factors. in NATO Security through Science Series C: Environmental Security. NATO Security through Science Series C: Environmental Security, pp. 63-75. https://doi.org/10.1007/978-1-4020-6469-2-5
Richard Stanley E. Regulation of hematopoiesis by growth factors. In NATO Security through Science Series C: Environmental Security. 2008. p. 63-75. (NATO Security through Science Series C: Environmental Security). https://doi.org/10.1007/978-1-4020-6469-2-5
Richard Stanley, E. / Regulation of hematopoiesis by growth factors. NATO Security through Science Series C: Environmental Security. 2008. pp. 63-75 (NATO Security through Science Series C: Environmental Security).
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