Regulation of granulopoiesis by transcription factors and cytokine signals

A. C. Ward, D. M. Loeb, A. A. Soede-Bobok, I. P. Touw, A. D. Friedman

Research output: Contribution to journalReview article

92 Scopus citations

Abstract

The development of mature granulocytes from hematopoietic precursor cells is controlled by a myriad of transcription factors which regulate the expression of essential genes, including those encoding growth factors and their receptors, enzymes, adhesion molecules, and transcription factors themselves. In particular, C/EBPα, PU.1, CBF, and c-Myb have emerged as critical players during early granulopoiesis. These transcription factors interact with one another as well as other factors to regulate the expression of a variety of genes important in granulocytic lineage commitment. An important goal remains to understand in greater detail how these various factors act in concert with signals emanating from cytokine receptors to influence the various steps of maturation, from the pluripotent hematopoietic stem cell, to a committed myeloid progenitor, to myeloid precursors, and ultimately to mature granulocytes.

Original languageEnglish (US)
Pages (from-to)973-990
Number of pages18
JournalLeukemia
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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Keywords

  • C/EBPα
  • Cytokine receptor
  • G-CSF-R
  • Granulopoiesis
  • PU.1
  • Transcription factors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Ward, A. C., Loeb, D. M., Soede-Bobok, A. A., Touw, I. P., & Friedman, A. D. (2000). Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia, 14(6), 973-990. https://doi.org/10.1038/sj.leu.2401808