Regulation Of Feeding Behavior By Glucagonlike Peptide 1 (GLP-1)

Patricia M. Vuguin, Maureen J. Charron

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter focuses on glucagonlike peptide 1 (GLP-l) and its role in the regulation of feeding behavior. GLP-1 is a posttranslational product of the proglucagon gene. GLP-1 is released in response to meals and acts as a satiety signal. High GLP-1 concentrations as well as the widespread distribution of its receptor in the central nervous system have suggested a central role for GLP-1 in appetite suppression. GLP-1 meets the major criteria required for a neuropeptide. It is synthesized from preproglucagon by noncatecholaminergic and leptin receptor positive neurons of nucleus of the solitary tract (NTS) and the dorsal and ventral part of the reticular nucleus. GLP-1 concentrations within the physiological range reduced food intake by 21% in lean subjects. In humans, GLP-1 infusion decreased postprandial feelings of hunger, suggesting a decreased rate of entry of nutrients into the circulation by reducing the gastric emptying rate. GLP-1 infusion rate was found to be the only independent predictor of the reduction in energy intake in both lean and obese subjects.

Original languageEnglish (US)
Title of host publicationHandbook of Biologically Active Peptides
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780123694423
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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