Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4

Emanuela Lacana', Luciano D'Adamio

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Programmed cell death is a process required for the normal development of an organism. One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction. During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death. Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis. These results indicate that ALG-4 is necessary and sufficient for FasL expression. Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise. Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)542-547
Number of pages6
JournalNature Medicine
Volume5
Issue number5
DOIs
StatePublished - May 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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