Regulation and metabolic significance of De Novo lipogenesis in adipose tissues

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

De novo lipogenesis (DNL) is a complex and highly regulated process in which carbohydrates from circulation are converted into fatty acids that are then used for synthesizing either triglycerides or other lipid molecules. Dysregulation of DNL contributes to human diseases such as obesity, type 2 diabetes, and cardiovascular diseases. Thus, the lipogenic pathway may provide a new therapeutic opportunity for combating various pathological conditions that are associated with dysregulated lipid metabolism. Hepatic DNL has been well documented, but lipogenesis in adipocytes and its contribution to energy homeostasis and insulin sensitivity are less studied. Recent reports have gained significant insights into the signaling pathways that regulate lipogenic transcription factors and the role of DNL in adipose tissues. In this review, we will update the current knowledge of DNL in white and brown adipose tissues with the focus on transcriptional, post-translational, and central regulation of DNL. We will also summarize the recent findings of adipocyte DNL as a source of some signaling molecules that critically regulate energy metabolism.

Original languageEnglish (US)
Article number1383
JournalNutrients
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Lipogenesis
lipogenesis
adipose tissue
Adipose Tissue
adipocytes
Adipocytes
White Adipose Tissue
white adipose tissue
Brown Adipose Tissue
brown adipose tissue
Lipid Metabolism
human diseases
noninsulin-dependent diabetes mellitus
insulin resistance
lipid metabolism
energy metabolism
Type 2 Diabetes Mellitus
Energy Metabolism
cardiovascular diseases
Insulin Resistance

Keywords

  • Adipocyte
  • Central regulation
  • ChREBP
  • De novo lipogenesis
  • FASN
  • Insulin resistance
  • LXR
  • Obesity
  • Post-translation
  • SREBP
  • Thermogenesis
  • Transcription

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Regulation and metabolic significance of De Novo lipogenesis in adipose tissues. / Song, Ziyi; Xiaoli, Alus Michael; Yang, Fajun.

In: Nutrients, Vol. 10, No. 10, 1383, 01.10.2018.

Research output: Contribution to journalReview article

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