Regulated nuclear entry of the C. elegans Pax-6 transcription factor

Yinhua Zhang, Henrique B. Ferreira, David Greenstein, Andrew Chisholm, Scott W. Emmons

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

It is shown that the C. elegans Pax-6 locus encodes two protein isoforms. One contains a Paired DNA binding domain as well as a homeodomain; the other consists only of the carboxy-terminal portion of the locus encoding the homeodomain. These two isoforms are expressed in a variety of postembryonic cell lineages. In one set of lineages, nuclear localization of a homeodomain-only form (MAB-18 isoform) appears to be under temporal and spatial control. Nuclear localization of MAlt-18 is correlated with the genetic requirement for mab-18 and with activation of a reporter gene driven by a mab-18 promoter. Reporter gene expression is dependent on mab-18 gene activity. It is hypothesized that a positive feedback loop is activated by regulated nuclear entry.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalMechanisms of Development
Volume78
Issue number1-2
DOIs
StatePublished - Dec 29 1998

Keywords

  • Caenorhabditis elegans
  • Homeodomain protein
  • Pax-6
  • mab-18
  • vab-3

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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