Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes

Robert T. Watson, Makoto Kanzaki, Jeffrey E. Pessin

Research output: Contribution to journalArticle

319 Citations (Scopus)

Abstract

Since the discovery of insulin roughly 80 yr ago, much has been learned about how target cells receive, interpret, and respond to this peptide hormone. For example, we now know that insulin activates the tyrosine kinase activity of its cell surface receptor, thereby triggering intracellular signaling cascades that regulate many cellular processes. With respect to glucose homeostasis, these include the function of insulin to suppress hepatic glucose production and to increase glucose uptake in muscle and adipose tissues, the latter resulting from the translocation of the glucose transporter 4 (GLUT4) to the cell surface membrane. Although simple in broad outline, elucidating the molecular intricacies of these receptor-signaling path ways and membrane-trafficking processes continues to challenge the creative ingenuity of scientists, and many questions remain unresolved, or even perhaps unasked. The identification and functional characterization of specific molecules required for both insulin signaling and GLUT4 vesicle trafficking remain key issues in our pursuit of developing specific therapeutic agents to treat and/or prevent this debilitating disease process. To this end, the combined efforts of numerous research groups employing a range of experimental approaches has led to a clearer molecular picture of how insulin regulates the membrane trafficking of GLUT4.

Original languageEnglish (US)
Pages (from-to)177-204
Number of pages28
JournalEndocrine Reviews
Volume25
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Glucose Transporter Type 4
Adipocytes
Facilitative Glucose Transport Proteins
Insulin
Membranes
Glucose
Peptide Hormones
Cell Surface Receptors
Protein-Tyrosine Kinases
Adipose Tissue
Homeostasis
Cell Membrane
Muscles
Liver
Research

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. / Watson, Robert T.; Kanzaki, Makoto; Pessin, Jeffrey E.

In: Endocrine Reviews, Vol. 25, No. 2, 04.2004, p. 177-204.

Research output: Contribution to journalArticle

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