Regulated expression of Ly-6A.2 is important for T cell development

A. Bamezai, D. Palliser, A. Berezovskaya, J. McGrew, K. Higgins, E. Lacy, K. L. Rock

Research output: Contribution to journalArticle

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Abstract

Ly-6A.2 is a surface protein on T cells that may play a role in lymphocyte activation. The regulation of Ly-6A.2 expression during T cell lymphopoiesis has been intriguing. It is one of the earliest markers expressed on pluripotent hemopoietic stem cells and is present on both primitive and mature T cells, but its expression is extinguished in the thymus during key developmental stages. To determine whether Ly-6A.2 is active on developing T cells, as well as the significance of its developmental regulation, Ly-6A.2 was expressed throughout T cell development under control of the T cell- specific human CD2 enhancer in transgenic mice. The constitutive overexpression of Ly-6A.2 in vivo led to a marked impairment in the generation of thymocytes. Development was arrested at the time in thymic development when Ly-6A.2 expression is normally turned off. These results indicate that the regulated expression of Ly-6A.2 in thymocytes may be important for normal development. Moreover, these findings demonstrate that Ly-6A.2 is active in the thymic microenvironment.

Original languageEnglish (US)
Pages (from-to)4233-4239
Number of pages7
JournalJournal of Immunology
Volume154
Issue number9
StatePublished - 1995
Externally publishedYes

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T-Lymphocytes
Thymocytes
Lymphopoiesis
Pluripotent Stem Cells
Lymphocyte Activation
Thymus Gland
Transgenic Mice
Membrane Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Bamezai, A., Palliser, D., Berezovskaya, A., McGrew, J., Higgins, K., Lacy, E., & Rock, K. L. (1995). Regulated expression of Ly-6A.2 is important for T cell development. Journal of Immunology, 154(9), 4233-4239.

Regulated expression of Ly-6A.2 is important for T cell development. / Bamezai, A.; Palliser, D.; Berezovskaya, A.; McGrew, J.; Higgins, K.; Lacy, E.; Rock, K. L.

In: Journal of Immunology, Vol. 154, No. 9, 1995, p. 4233-4239.

Research output: Contribution to journalArticle

Bamezai, A, Palliser, D, Berezovskaya, A, McGrew, J, Higgins, K, Lacy, E & Rock, KL 1995, 'Regulated expression of Ly-6A.2 is important for T cell development', Journal of Immunology, vol. 154, no. 9, pp. 4233-4239.
Bamezai A, Palliser D, Berezovskaya A, McGrew J, Higgins K, Lacy E et al. Regulated expression of Ly-6A.2 is important for T cell development. Journal of Immunology. 1995;154(9):4233-4239.
Bamezai, A. ; Palliser, D. ; Berezovskaya, A. ; McGrew, J. ; Higgins, K. ; Lacy, E. ; Rock, K. L. / Regulated expression of Ly-6A.2 is important for T cell development. In: Journal of Immunology. 1995 ; Vol. 154, No. 9. pp. 4233-4239.
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AU - Rock, K. L.

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