Regulated expression of Ly-6A.2 is important for T cell development

A. Bamezai, D. Palliser, A. Berezovskaya, J. McGrew, K. Higgins, E. Lacy, K. L. Rock

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Ly-6A.2 is a surface protein on T cells that may play a role in lymphocyte activation. The regulation of Ly-6A.2 expression during T cell lymphopoiesis has been intriguing. It is one of the earliest markers expressed on pluripotent hemopoietic stem cells and is present on both primitive and mature T cells, but its expression is extinguished in the thymus during key developmental stages. To determine whether Ly-6A.2 is active on developing T cells, as well as the significance of its developmental regulation, Ly-6A.2 was expressed throughout T cell development under control of the T cell- specific human CD2 enhancer in transgenic mice. The constitutive overexpression of Ly-6A.2 in vivo led to a marked impairment in the generation of thymocytes. Development was arrested at the time in thymic development when Ly-6A.2 expression is normally turned off. These results indicate that the regulated expression of Ly-6A.2 in thymocytes may be important for normal development. Moreover, these findings demonstrate that Ly-6A.2 is active in the thymic microenvironment.

Original languageEnglish (US)
Pages (from-to)4233-4239
Number of pages7
JournalJournal of Immunology
Volume154
Issue number9
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Bamezai, A., Palliser, D., Berezovskaya, A., McGrew, J., Higgins, K., Lacy, E., & Rock, K. L. (1995). Regulated expression of Ly-6A.2 is important for T cell development. Journal of Immunology, 154(9), 4233-4239.