Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress

Hongwei Li, Aming Liang, Fangxia Guan, Ruitai Fan, Liankai Chi, Bo Yang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A substantial amount of evidence has shown that treadmill running enhances neurogenesis, improves cognitive function, and protects the brain against neurodegenerative disorders. However, treadmill running is a type of forced exercise that could increase the level of corticosterone, which subsequently down-regulates neurogenesis and impairs cognitive function. The purpose of this study was to investigate if regular treadmill running provides a balance between the positive and negative effects of treadmill running. The mice were divided into four groups: controls (CON), regular runners (RR), irregular duration runners (IDR) and irregular time-of-day runners (ITR). The RR mice ran daily on the treadmill at the same time-of-day, speed and duration. The IDR mice ran at the same time-of-day and speed, but for a different duration. The ITR mice ran at the same speed and duration, but at different time-of-day. The results showed that regular treadmill running could increase neurogenesis and improve spatial learning and memory performance, as well as decrease the level of corticosterone. The present finding emphasizes the importance of regular physical exercise on cognition.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBrain Research
Volume1531
DOIs
StatePublished - Sep 19 2013
Externally publishedYes

Fingerprint

Neurogenesis
Running
Cognition
Corticosterone
Neurodegenerative Diseases
Down-Regulation
Spatial Memory
Spatial Learning
Exercise
Control Groups
Brain

Keywords

  • C57BL/6 mice
  • Cognition
  • Corticosterone
  • Neurogenesis
  • Treadmill

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress. / Li, Hongwei; Liang, Aming; Guan, Fangxia; Fan, Ruitai; Chi, Liankai; Yang, Bo.

In: Brain Research, Vol. 1531, 19.09.2013, p. 1-8.

Research output: Contribution to journalArticle

Li, Hongwei ; Liang, Aming ; Guan, Fangxia ; Fan, Ruitai ; Chi, Liankai ; Yang, Bo. / Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress. In: Brain Research. 2013 ; Vol. 1531. pp. 1-8.
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