Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease

Yevgeniy Balagula, Janis M. Taube, Timothy Wang, Amir H. Dorafshar, Ronald J. Sweren

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Numerous complications can be observed in the post-transplant period among recipients of hematopoietic stem cells including graft-versus-host disease (GVHD), which is associated with significant morbidity and mortality. On the other hand, graft versus tumor (GVT) effect is a well-described phenomenon in patients with hematologic malignancies and has also been reported in renal cell cancer, ovarian cancer, breast carcinoma, and melanoma. We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal proliferations in a patient with chronic graft-versus-host disease following initiation of extracorporeal photopheresis (ECP). This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP.

Original languageEnglish (US)
Article number8
JournalDermatology Online Journal
Volume20
Issue number5
StatePublished - 2014
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Dermatology

Cite this