Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease

Yevgeniy Balagula, Janis M. Taube, Timothy Wang, Amir H. Dorafshar, Ronald J. Sweren

Research output: Contribution to journalArticle

Abstract

Numerous complications can be observed in the post-transplant period among recipients of hematopoietic stem cells including graft-versus-host disease (GVHD), which is associated with significant morbidity and mortality. On the other hand, graft versus tumor (GVT) effect is a well-described phenomenon in patients with hematologic malignancies and has also been reported in renal cell cancer, ovarian cancer, breast carcinoma, and melanoma. We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal proliferations in a patient with chronic graft-versus-host disease following initiation of extracorporeal photopheresis (ECP). This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP.

Original languageEnglish (US)
Article number8
JournalDermatology Online Journal
Volume20
Issue number5
StatePublished - 2014
Externally publishedYes

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Graft vs Host Disease
Photopheresis
Squamous Cell Carcinoma
Transplants
Skin
Breast Neoplasms
Skin Neoplasms
Hematologic Neoplasms
Hematopoietic Stem Cells
Renal Cell Carcinoma
Ovarian Neoplasms
Melanoma
Neoplasms
Morbidity
Mortality

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease. / Balagula, Yevgeniy; Taube, Janis M.; Wang, Timothy; Dorafshar, Amir H.; Sweren, Ronald J.

In: Dermatology Online Journal, Vol. 20, No. 5, 8, 2014.

Research output: Contribution to journalArticle

Balagula, Yevgeniy ; Taube, Janis M. ; Wang, Timothy ; Dorafshar, Amir H. ; Sweren, Ronald J. / Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease. In: Dermatology Online Journal. 2014 ; Vol. 20, No. 5.
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